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ASPA

GENERAL INFORMATION

Gene name

 ASPA

Gene description

 Aspartoacylase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (renal cancer)
HPA (cell line):Cell line enhanced (ASC TERT1, CACO-2)
HPA (normal tissue):Tissue enhanced (kidney)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct expression mainly in renal tubules and glial cells in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA022142
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA022142

GENE INFORMATION

Gene name

 ASPA (HGNC Symbol)

Synonyms

 ACY2, ASP

Description

 Aspartoacylase (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 3472374 - 3503419

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108381 (version 83.38)

Entrez gene

 443

UniProt

 P45381 (UniProt - Evidence at protein level)

neXtProt

 NX_P45381

Antibodypedia

 ASPA antibodies

PROTEIN BROWSER
ASPA-001
ASPA-002
ASPA-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ASPA-001
ENSP00000263080
ENST00000263080
P45381 [Direct mapping]
Aspartoacylase
Q6FH48 [Target identity:100%; Query identity:100%]
ASPA protein; Aspartoacylase (Canavan disease), isoform CRA_a; cDNA, FLJ93347, Homo sapiens aspartoacylase (aminoacylase 2, Canavan disease)(ASPA), mRNA
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004046 [aminoacylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006533 [aspartate catabolic process]
GO:0008152 [metabolic process]
GO:0008652 [cellular amino acid biosynthetic process]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides]
GO:0019807 [aspartoacylase activity]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
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 313 aa
35.7 kDa 		No 0
ASPA-002
ENSP00000409976
ENST00000456349
P45381 [Direct mapping]
Aspartoacylase
Q6FH48 [Target identity:100%; Query identity:100%]
ASPA protein; Aspartoacylase (Canavan disease), isoform CRA_a; cDNA, FLJ93347, Homo sapiens aspartoacylase (aminoacylase 2, Canavan disease)(ASPA), mRNA
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004046 [aminoacylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006533 [aspartate catabolic process]
GO:0008152 [metabolic process]
GO:0008652 [cellular amino acid biosynthetic process]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides]
GO:0019807 [aspartoacylase activity]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
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 313 aa
35.7 kDa 		No 0
ASPA-003
ENSP00000458324
ENST00000577034
I3L0T3 [Direct mapping]
Aspartoacylase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0008152 [metabolic process]
GO:0016788 [hydrolase activity, acting on ester bonds]
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 79 aa
8.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.