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RPS6KB1

GENERAL INFORMATION

Gene name

 RPS6KB1

Gene description

 Ribosomal protein S6 kinase, 70kDa, polypeptide 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and nuclear expression in a few tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA039442 , CAB003838 , CAB018346
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039442
CAB003838
CAB018346

GENE INFORMATION

Gene name

 RPS6KB1 (HGNC Symbol)

Synonyms

 p70(S6K)-alpha, PS6K, S6K1, STK14A

Description

 Ribosomal protein S6 kinase, 70kDa, polypeptide 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]

Chromosome

 17

Cytoband

 q23.1

Chromosome location (bp)

 59893046 - 59950564

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108443 (version 83.38)

Entrez gene

 6198

UniProt

 P23443 (UniProt - Evidence at protein level)

neXtProt

 NX_P23443

Antibodypedia

 RPS6KB1 antibodies

PROTEIN BROWSER
RPS6KB1-001
RPS6KB1-002
RPS6KB1-007
RPS6KB1-008
RPS6KB1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPS6KB1-001
ENSP00000225577
ENST00000225577
P23443 [Direct mapping]
Ribosomal protein S6 kinase beta-1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0001662 [behavioral fear response]
GO:0003009 [skeletal muscle contraction]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007281 [germ cell development]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0007616 [long-term memory]
GO:0008286 [insulin receptor signaling pathway]
GO:0009408 [response to heat]
GO:0009611 [response to wounding]
GO:0009612 [response to mechanical stimulus]
GO:0009636 [response to toxic substance]
GO:0009749 [response to glucose]
GO:0009986 [cell surface]
GO:0010033 [response to organic substance]
GO:0010243 [response to organonitrogen compound]
GO:0014070 [response to organic cyclic compound]
GO:0014732 [skeletal muscle atrophy]
GO:0014878 [response to electrical stimulus involved in regulation of muscle adaptation]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0016477 [cell migration]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0031929 [TOR signaling]
GO:0032496 [response to lipopolysaccharide]
GO:0032868 [response to insulin]
GO:0032869 [cellular response to insulin stimulus]
GO:0032870 [cellular response to hormone stimulus]
GO:0033574 [response to testosterone]
GO:0033762 [response to glucagon]
GO:0034612 [response to tumor necrosis factor]
GO:0042277 [peptide binding]
GO:0042493 [response to drug]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043200 [response to amino acid]
GO:0043201 [response to leucine]
GO:0043434 [response to peptide hormone]
GO:0043491 [protein kinase B signaling]
GO:0045202 [synapse]
GO:0045471 [response to ethanol]
GO:0045727 [positive regulation of translation]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045948 [positive regulation of translational initiation]
GO:0046324 [regulation of glucose import]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048633 [positive regulation of skeletal muscle tissue growth]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0051384 [response to glucocorticoid]
GO:0051721 [protein phosphatase 2A binding]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 525 aa
59.1 kDa 		No 0
RPS6KB1-002
ENSP00000384335
ENST00000406116
P23443 [Direct mapping]
Ribosomal protein S6 kinase beta-1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0030054 [cell junction]
GO:0031929 [TOR signaling]
GO:0032869 [cellular response to insulin stimulus]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0045202 [synapse]
GO:0045727 [positive regulation of translation]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045948 [positive regulation of translational initiation]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0071363 [cellular response to growth factor stimulus]
Show all
 451 aa
51 kDa 		No 0
RPS6KB1-007
ENSP00000464805
ENST00000592726
K7EIM2 [Direct mapping]
Ribosomal protein S6 kinase beta-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0006468 [protein phosphorylation]
GO:0032869 [cellular response to insulin stimulus]
Show all
 62 aa
6.9 kDa 		No 0
RPS6KB1-008
ENSP00000441993
ENST00000443572
P23443 [Direct mapping]
Ribosomal protein S6 kinase beta-1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0030054 [cell junction]
GO:0031929 [TOR signaling]
GO:0032869 [cellular response to insulin stimulus]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0045202 [synapse]
GO:0045727 [positive regulation of translation]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045948 [positive regulation of translational initiation]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0071363 [cellular response to growth factor stimulus]
Show all
 502 aa
56.6 kDa 		No 0
RPS6KB1-201
ENSP00000376744
ENST00000393021
P23443 [Direct mapping]
Ribosomal protein S6 kinase beta-1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0030054 [cell junction]
GO:0031929 [TOR signaling]
GO:0032869 [cellular response to insulin stimulus]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0045202 [synapse]
GO:0045727 [positive regulation of translation]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045948 [positive regulation of translational initiation]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0071363 [cellular response to growth factor stimulus]
Show all
 472 aa
53 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.