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RECQL5

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GENERAL INFORMATION

Gene name

 RECQL5

Gene description

 RecQ helicase-like 5

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus. In addition localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

Additional location

 In addition localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA029971
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus. In addition localized to the cytosol.

Main location

 Nucleus (supported)

Additional location

 Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA029971 A-431 Nucleus
Cytosol
HPA029971 U-2 OS Nucleoplasm
Cytosol
HPA029971 U-251 MG Nucleus
Cytosol

GENE INFORMATION

Gene name

 RECQL5 (HGNC Symbol)

Synonyms

 FLJ90603, RecQ5

Description

 RecQ helicase-like 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Chromosome

 17

Cytoband

 q25.1

Chromosome location (bp)

 75626845 - 75667189

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108469 (version 83.38)

Entrez gene

 9400

UniProt

 O94762 (UniProt - Evidence at protein level)

neXtProt

 NX_O94762

Antibodypedia

 RECQL5 antibodies

PROTEIN BROWSER
RECQL5-001
RECQL5-002
RECQL5-003
RECQL5-004
RECQL5-005
RECQL5-010
RECQL5-014
RECQL5-018
RECQL5-019
RECQL5-020

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RECQL5-001
ENSP00000317636
ENST00000317905
O94762 [Direct mapping]
ATP-dependent DNA helicase Q5
A0A024R8M9 [Target identity:100%; Query identity:100%]
RecQ protein-like 5, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000993 [RNA polymerase II core binding]
GO:0003676 [nucleic acid binding]
GO:0003678 [DNA helicase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006259 [DNA metabolic process]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0007067 [mitotic nuclear division]
GO:0008026 [ATP-dependent helicase activity]
GO:0016591 [DNA-directed RNA polymerase II, holoenzyme]
GO:0031965 [nuclear membrane]
GO:0032508 [DNA duplex unwinding]
GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter]
GO:0051301 [cell division]
GO:0051304 [chromosome separation]
Show all
 991 aa
108.9 kDa 		No 0
RECQL5-002
ENSP00000394820
ENST00000423245
O94762 [Direct mapping]
ATP-dependent DNA helicase Q5
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000993 [RNA polymerase II core binding]
GO:0003676 [nucleic acid binding]
GO:0003678 [DNA helicase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006259 [DNA metabolic process]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0007067 [mitotic nuclear division]
GO:0008026 [ATP-dependent helicase activity]
GO:0016591 [DNA-directed RNA polymerase II, holoenzyme]
GO:0031965 [nuclear membrane]
GO:0032508 [DNA duplex unwinding]
GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter]
GO:0051301 [cell division]
GO:0051304 [chromosome separation]
Show all
 964 aa
106.1 kDa 		No 0
RECQL5-003
ENSP00000462248
ENST00000584999
O94762 [Direct mapping]
ATP-dependent DNA helicase Q5
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000993 [RNA polymerase II core binding]
GO:0003676 [nucleic acid binding]
GO:0003678 [DNA helicase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006259 [DNA metabolic process]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0007067 [mitotic nuclear division]
GO:0008026 [ATP-dependent helicase activity]
GO:0016591 [DNA-directed RNA polymerase II, holoenzyme]
GO:0031965 [nuclear membrane]
GO:0032508 [DNA duplex unwinding]
GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter]
GO:0051301 [cell division]
GO:0051304 [chromosome separation]
Show all
 435 aa
48.5 kDa 		No 0
RECQL5-004
ENSP00000341983
ENST00000340830
O94762 [Direct mapping]
ATP-dependent DNA helicase Q5
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000993 [RNA polymerase II core binding]
GO:0003676 [nucleic acid binding]
GO:0003678 [DNA helicase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006259 [DNA metabolic process]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0007067 [mitotic nuclear division]
GO:0008026 [ATP-dependent helicase activity]
GO:0016591 [DNA-directed RNA polymerase II, holoenzyme]
GO:0031965 [nuclear membrane]
GO:0032508 [DNA duplex unwinding]
GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter]
GO:0051301 [cell division]
GO:0051304 [chromosome separation]
Show all
 435 aa
48.5 kDa 		No 0
RECQL5-005
ENSP00000463099
ENST00000578201
J3KTQ2 [Direct mapping]
ATP-dependent DNA helicase Q5
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005524 [ATP binding]
GO:0006310 [DNA recombination]
GO:0008026 [ATP-dependent helicase activity]
Show all
 480 aa
53.2 kDa 		No 0
RECQL5-010
ENSP00000462547
ENST00000580078
J3KSL7 [Direct mapping]
ATP-dependent DNA helicase Q5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005524 [ATP binding]
GO:0008026 [ATP-dependent helicase activity]
GO:0008152 [metabolic process]
Show all
 198 aa
22.2 kDa 		No 0
RECQL5-014
ENSP00000463701
ENST00000580707
J3QLU0 [Direct mapping]
ATP-dependent DNA helicase Q5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
Show all
 190 aa
21.1 kDa 		No 0
RECQL5-018
ENSP00000462291
ENST00000582548
J3KS37 [Direct mapping]
ATP-dependent DNA helicase Q5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 236 aa
24.9 kDa 		No 0
RECQL5-019
ENSP00000462678
ENST00000581825
J3KSV9 [Direct mapping]
ATP-dependent DNA helicase Q5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 206 aa
21.5 kDa 		No 0
RECQL5-020
ENSP00000414933
ENST00000420326
O94762 [Direct mapping]
ATP-dependent DNA helicase Q5
A0A024R8S8 [Target identity:100%; Query identity:100%]
RecQ protein-like 5, isoform CRA_e
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000993 [RNA polymerase II core binding]
GO:0003676 [nucleic acid binding]
GO:0003678 [DNA helicase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006259 [DNA metabolic process]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0007067 [mitotic nuclear division]
GO:0008026 [ATP-dependent helicase activity]
GO:0016591 [DNA-directed RNA polymerase II, holoenzyme]
GO:0031965 [nuclear membrane]
GO:0032508 [DNA duplex unwinding]
GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter]
GO:0051301 [cell division]
GO:0051304 [chromosome separation]
Show all
 410 aa
45.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.