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Most colorectal, pancreatic and cervical cancers as well as several cases of endometrial cancers exhibited weak to moderate cytoplasmic and/or membranous immunoreactivity. Remaining tumors were mainly negative.
Most cancer tissues were negative. Several thyroid cancers along with rare cases of hepatocellular carcinomas displayed moderate cytoplasmic immunoreactivity.
GENE INFORMATION
Gene name
RECQL5 (HGNC Symbol)
Synonyms
FLJ90603, RecQ5
Description
RecQ helicase-like 5 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
O94762 [Direct mapping] ATP-dependent DNA helicase Q5
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Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)