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Gliomas and renal cancers as well as several prostate, endometrial, urothelial showed moderate nuclear staining. Remaining cancers were weakly stained or negative.
Moderate to strong nuclear membranous or cytoplasmic positivity was observed in several cases of colorectal, endometrial, thyroid, testicular, urothelial and liver cancers. Remaining cancer cells were weakly stained or negative.
GENE INFORMATION
Gene name
NUP88 (HGNC Symbol)
Synonyms
MGC8530
Description
Nucleoporin 88kDa (HGNC Symbol)
Entrez gene summary
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. [provided by RefSeq, Jul 2008]
Q99567 [Direct mapping] Nuclear pore complex protein Nup88
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Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)