Expression of BLMH in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	BLMH
Gene description	Bleomycin hydrolase
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a subset of tissues including keratinocytes in skin and cells in seminiferous ducts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA039548 , HPA064307
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA039548	HPA064307

GENE INFORMATION
Gene name	BLMH (HGNC Symbol)
Synonyms	BH
Description	Bleomycin hydrolase (HGNC Symbol)
Entrez gene summary	Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q11.2
Chromosome location (bp)	30248195 - 30292056
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108578 (version 83.38)
Entrez gene	642
UniProt	Q13867 (UniProt - Evidence at protein level)
neXtProt	NX_Q13867
Antibodypedia	BLMH antibodies

PROTEIN BROWSER

BLMH-001	BLMH-005	BLMH-006	BLMH-009	BLMH-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BLMH-001 ENSP00000261714 ENST00000261714	Q13867 [Direct mapping] Bleomycin hydrolase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000209 [protein polyubiquitination] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0004177 [aminopeptidase activity] GO:0004180 [carboxypeptidase activity] GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0009636 [response to toxic substance] GO:0042493 [response to drug] GO:0070062 [extracellular exosome] Show all	455 aa 52.6 kDa	No	0
BLMH-005 ENSP00000462442 ENST00000581037	J3KSD8 [Direct mapping] Bleomycin hydrolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] Show all	263 aa 30.4 kDa	No	0
BLMH-006 ENSP00000468681 ENST00000577623	K7ESE8 [Direct mapping] Bleomycin hydrolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	231 aa 26.7 kDa	No	0
BLMH-009 ENSP00000466527 ENST00000580709	K7EMJ3 [Direct mapping] Bleomycin hydrolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	67 aa 8.1 kDa	No	0
BLMH-010 ENSP00000468486 ENST00000584603	K7ES02 [Direct mapping] Bleomycin hydrolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] Show all	318 aa 37.2 kDa	No	0