Fields »
ABOUT
HELP
BLOG
BLMH

GENERAL INFORMATION

Gene name

 BLMH

Gene description

 Bleomycin hydrolase

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Tissue enriched (skin)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a subset of tissues including keratinocytes in skin and cells in seminiferous ducts.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA039548 , HPA064307
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 BLMH (HGNC Symbol)

Synonyms

 BH

Description

 Bleomycin hydrolase (HGNC Symbol)

Entrez gene summary

 Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q11.2

Chromosome location (bp)

 30248195 - 30292056

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108578 (version 83.38)

Entrez gene

 642

UniProt

 Q13867 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13867

Antibodypedia

 BLMH antibodies

PROTEIN BROWSER
BLMH-001
BLMH-005
BLMH-006
BLMH-009
BLMH-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BLMH-001
ENSP00000261714
ENST00000261714
Q13867 [Direct mapping]
Bleomycin hydrolase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0004177 [aminopeptidase activity]
GO:0004180 [carboxypeptidase activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0009636 [response to toxic substance]
GO:0042493 [response to drug]
GO:0070062 [extracellular exosome]
Show all
 455 aa
52.6 kDa 		No 0
BLMH-005
ENSP00000462442
ENST00000581037
J3KSD8 [Direct mapping]
Bleomycin hydrolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
Show all
 263 aa
30.4 kDa 		No 0
BLMH-006
ENSP00000468681
ENST00000577623
K7ESE8 [Direct mapping]
Bleomycin hydrolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0006508 [proteolysis]
Show all
 231 aa
26.7 kDa 		No 0
BLMH-009
ENSP00000466527
ENST00000580709
K7EMJ3 [Direct mapping]
Bleomycin hydrolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0006508 [proteolysis]
Show all
 67 aa
8.1 kDa 		No 0
BLMH-010
ENSP00000468486
ENST00000584603
K7ES02 [Direct mapping]
Bleomycin hydrolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
Show all
 318 aa
37.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.