Cell atlas - CPD - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CPD
Gene description	Carboxypeptidase D
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles & nucleoplasm. In addition localized to the nuclear membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Nuclear speckles (approved)
Additional location	In addition localized to the Nuclear membrane (approved)
Mouse	Localized to the Nuclear speckles in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA055465
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles & nucleoplasm. In addition localized to the nuclear membrane.

Main location

Nucleoplasm (approved), Nuclear speckles (approved)

Additional location

Nuclear membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA055465	CACO-2	Nucleoplasm
HPA055465	CACO-2	Nuclear membrane
HPA055465	HEK 293	Nuclear membrane
HPA055465	HEK 293	Nuclear speckles
HPA055465	U-2 OS	Nucleoplasm

MOUSE CELLS

Main location

Nuclear speckles

Mouse gene

ENSMUSG00000020841 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA055465	NIH 3T3	Nuclear speckles

GENE INFORMATION
Gene name	CPD (HGNC Symbol)
Synonyms	GP180
Description	Carboxypeptidase D (HGNC Symbol)
Entrez gene summary	The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q11.2
Chromosome location (bp)	30378905 - 30469989
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108582 (version 83.38)
Entrez gene	1362
UniProt	O75976 (UniProt - Evidence at protein level)
neXtProt	NX_O75976
Antibodypedia	CPD antibodies

PROTEIN BROWSER

CPD-001	CPD-003	CPD-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPD-001 ENSP00000225719 ENST00000225719	O75976 [Direct mapping] Carboxypeptidase D Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	1380 aa 152.9 kDa	Yes	1
CPD-003 ENSP00000444443 ENST00000543464	O75976 [Direct mapping] Carboxypeptidase D Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	1133 aa 126.5 kDa	No	1
CPD-006 ENSP00000463763 ENST00000584221	J3QQJ4 [Direct mapping] Carboxypeptidase D Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		184 aa 20.2 kDa	No	0