Expression of CPD in cancer - Summary - The Human Protein Atlas

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CPD

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CPD
Gene description	Carboxypeptidase D
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA052796
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052796

GENE INFORMATION
Gene name	CPD (HGNC Symbol)
Synonyms	GP180
Description	Carboxypeptidase D (HGNC Symbol)
Entrez gene summary	The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q11.2
Chromosome location (bp)	30378905 - 30469989
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108582 (version 83.38)
Entrez gene	1362
UniProt	O75976 (UniProt - Evidence at protein level)
neXtProt	NX_O75976
Antibodypedia	CPD antibodies

PROTEIN BROWSER

CPD-001	CPD-003	CPD-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPD-001 ENSP00000225719 ENST00000225719	O75976 [Direct mapping] Carboxypeptidase D Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	1380 aa 152.9 kDa	Yes	1
CPD-003 ENSP00000444443 ENST00000543464	O75976 [Direct mapping] Carboxypeptidase D Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	1133 aa 126.5 kDa	No	1
CPD-006 ENSP00000463763 ENST00000584221	J3QQJ4 [Direct mapping] Carboxypeptidase D Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		184 aa 20.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.