Expression of CCDC47 in cancer - Summary - The Human Protein Atlas

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CCDC47

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCDC47
Gene description	Coiled-coil domain containing 47
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA029674
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029674

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Most malignant cells showed moderate cytoplasmic positivity. Strong cytoplasmic immunoreactivity was observed in few cases of malignant melanomas, breast, pancreatic and liver cancers. Several cases of malignant lymphomas, cervical and renal cancers were negative.

GENE INFORMATION
Gene name	CCDC47 (HGNC Symbol)
Synonyms	GK001
Description	Coiled-coil domain containing 47 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q23.3
Chromosome location (bp)	63745250 - 63776351
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108588 (version 83.38)
Entrez gene	57003
UniProt	Q96A33 (UniProt - Evidence at protein level)
neXtProt	NX_Q96A33
Antibodypedia	CCDC47 antibodies

PROTEIN BROWSER

CCDC47-001	CCDC47-002	CCDC47-003	CCDC47-005	CCDC47-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC47-001 ENSP00000225726 ENST00000225726	Q96A33 [Direct mapping] Coiled-coil domain-containing protein 47 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001649 [osteoblast differentiation] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005791 [rough endoplasmic reticulum] GO:0006983 [ER overload response] GO:0007029 [endoplasmic reticulum organization] GO:0009791 [post-embryonic development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0044822 [poly(A) RNA binding] GO:0055074 [calcium ion homeostasis] Show all	483 aa 55.9 kDa	Yes	1
CCDC47-002 ENSP00000384888 ENST00000403162	Q96A33 [Direct mapping] Coiled-coil domain-containing protein 47 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001649 [osteoblast differentiation] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0044822 [poly(A) RNA binding] Show all	483 aa 55.9 kDa	Yes	1
CCDC47-003 ENSP00000463577 ENST00000582252	Q96A33 [Direct mapping] Coiled-coil domain-containing protein 47 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001649 [osteoblast differentiation] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0044822 [poly(A) RNA binding] Show all	480 aa 55.3 kDa	Yes	1
CCDC47-005 ENSP00000462202 ENST00000580986	J3KRX4 [Direct mapping] Coiled-coil domain-containing protein 47 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		19 aa 2.1 kDa	No	0
CCDC47-201 ENSP00000482148 ENST00000612558	A0A087WYW6 [Direct mapping] Coiled-coil domain-containing protein 47 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		190 aa 22.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.