Cell atlas - AKAP10 - The Human Protein Atlas

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AKAP10

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	AKAP10
Gene description	A kinase (PRKA) anchor protein 10
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA028901
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cytosol.

Main location

Plasma membrane (approved), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA028901	A-431	Plasma membrane
	HPA028901	A-431	Cytosol
	HPA028901	U-2 OS	Plasma membrane	Intensity
	HPA028901	U-2 OS	Cytosol	Intensity
	HPA028901	U-251 MG	Plasma membrane
	HPA028901	U-251 MG	Cytosol

GENE INFORMATION
Gene name	AKAP10 (HGNC Symbol)
Synonyms	D-AKAP2, MGC9414, PRKA10
Description	A kinase (PRKA) anchor protein 10 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	19904302 - 19978343
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108599 (version 83.38)
Entrez gene	11216
UniProt	O43572 (UniProt - Evidence at protein level)
neXtProt	NX_O43572
Antibodypedia	AKAP10 antibodies

PROTEIN BROWSER

AKAP10-001	AKAP10-005	AKAP10-008	AKAP10-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AKAP10-001 ENSP00000225737 ENST00000225737	O43572 [Direct mapping] A-kinase anchor protein 10, mitochondrial Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] Show all	662 aa 73.8 kDa	No	0
AKAP10-005 ENSP00000378907 ENST00000395536	E7EMD6 [Direct mapping] A-kinase anchor protein 10, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] Show all	604 aa 67.8 kDa	No	0
AKAP10-008 ENSP00000458637 ENST00000576896	I3L177 [Direct mapping] A-kinase anchor protein 10, mitochondrial Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] Show all	138 aa 15.9 kDa	No	0
AKAP10-013 ENSP00000463398 ENST00000583951	J3QL61 [Direct mapping] A-kinase anchor protein 10, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] Show all	78 aa 8.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.