Expression of AKAP10 in cancer - Summary - The Human Protein Atlas

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AKAP10

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AKAP10
Gene description	A kinase (PRKA) anchor protein 10
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, most abundant in a subset of lymphocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA028901
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA028901

GENE INFORMATION
Gene name	AKAP10 (HGNC Symbol)
Synonyms	D-AKAP2, MGC9414, PRKA10
Description	A kinase (PRKA) anchor protein 10 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	19904302 - 19978343
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108599 (version 83.38)
Entrez gene	11216
UniProt	O43572 (UniProt - Evidence at protein level)
neXtProt	NX_O43572
Antibodypedia	AKAP10 antibodies

PROTEIN BROWSER

AKAP10-001	AKAP10-005	AKAP10-008	AKAP10-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AKAP10-001 ENSP00000225737 ENST00000225737	O43572 [Direct mapping] A-kinase anchor protein 10, mitochondrial Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] Show all	662 aa 73.8 kDa	No	0
AKAP10-005 ENSP00000378907 ENST00000395536	E7EMD6 [Direct mapping] A-kinase anchor protein 10, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] Show all	604 aa 67.8 kDa	No	0
AKAP10-008 ENSP00000458637 ENST00000576896	I3L177 [Direct mapping] A-kinase anchor protein 10, mitochondrial Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] Show all	138 aa 15.9 kDa	No	0
AKAP10-013 ENSP00000463398 ENST00000583951	J3QL61 [Direct mapping] A-kinase anchor protein 10, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] Show all	78 aa 8.8 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.