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RAB5C

GENERAL INFORMATION

Gene name

 RAB5C

Gene description

 RAB5C, member RAS oncogene family

Protein class

 Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA003426
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable).
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003426

GENE INFORMATION

Gene name

 RAB5C (HGNC Symbol)

Synonyms

 RAB5CL, RABL

Description

 RAB5C, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

 Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]).[supplied by OMIM, Nov 2010]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 42124976 - 42155044

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108774 (version 83.38)

Entrez gene

 5878

UniProt

 P51148 (UniProt - Evidence at protein level)

neXtProt

 NX_P51148

Antibodypedia

 RAB5C antibodies

PROTEIN BROWSER
RAB5C-001
RAB5C-002
RAB5C-004
RAB5C-005
RAB5C-006
RAB5C-008
RAB5C-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAB5C-001
ENSP00000345689
ENST00000346213
P51148 [Direct mapping]
Ras-related protein Rab-5C
A0A024R1U4 [Target identity:100%; Query identity:100%]
RAB5C, member RAS oncogene family, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005811 [lipid particle]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0030100 [regulation of endocytosis]
GO:0030139 [endocytic vesicle]
GO:0031901 [early endosome membrane]
GO:0032482 [Rab protein signal transduction]
GO:0042470 [melanosome]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048227 [plasma membrane to endosome transport]
GO:0070062 [extracellular exosome]
Show all
 216 aa
23.5 kDa 		No 0
RAB5C-002
ENSP00000447053
ENST00000547517
P51148 [Direct mapping]
Ras-related protein Rab-5C
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005811 [lipid particle]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007032 [endosome organization]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0030100 [regulation of endocytosis]
GO:0030139 [endocytic vesicle]
GO:0031901 [early endosome membrane]
GO:0032482 [Rab protein signal transduction]
GO:0042470 [melanosome]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048227 [plasma membrane to endosome transport]
GO:0070062 [extracellular exosome]
Show all
 249 aa
27 kDa 		No 0
RAB5C-004
ENSP00000449777
ENST00000550504
F8VWU4 [Direct mapping]
Ras-related protein Rab-5C
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0030100 [regulation of endocytosis]
GO:0030139 [endocytic vesicle]
GO:0032482 [Rab protein signal transduction]
Show all
 92 aa
10.1 kDa 		No 0
RAB5C-005
ENSP00000449612
ENST00000552162
F8VVK3 [Direct mapping]
Ras-related protein Rab-5C
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030100 [regulation of endocytosis]
GO:0030139 [endocytic vesicle]
GO:0032482 [Rab protein signal transduction]
Show all
 124 aa
13.6 kDa 		No 0
RAB5C-006
ENSP00000467144
ENST00000551338
K7ENY4 [Direct mapping]
Ras-related protein Rab-5C
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030100 [regulation of endocytosis]
GO:0030139 [endocytic vesicle]
GO:0032482 [Rab protein signal transduction]
Show all
 150 aa
17 kDa 		No 0
RAB5C-008
ENSP00000448314
ENST00000550406
F8VSF8 [Direct mapping]
Ras-related protein Rab-5C
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030100 [regulation of endocytosis]
GO:0030139 [endocytic vesicle]
GO:0032482 [Rab protein signal transduction]
Show all
 74 aa
7.8 kDa 		No 0
RAB5C-201
ENSP00000377440
ENST00000393860
P51148 [Direct mapping]
Ras-related protein Rab-5C
A0A024R1U4 [Target identity:100%; Query identity:100%]
RAB5C, member RAS oncogene family, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005811 [lipid particle]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0030100 [regulation of endocytosis]
GO:0030139 [endocytic vesicle]
GO:0031901 [early endosome membrane]
GO:0032482 [Rab protein signal transduction]
GO:0042470 [melanosome]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048227 [plasma membrane to endosome transport]
GO:0070062 [extracellular exosome]
Show all
 216 aa
23.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.