Tissue expression of ABI3 - Summary - The Human Protein Atlas

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ABI3

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ABI3
Gene description	ABI family, member 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (spleen)
GTEx:	Tissue enhanced (spleen)
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Mainly cytoplasmic expression in immune cells.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA017345
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ABI3 (HGNC Symbol)
Synonyms	NESH, SSH3BP3
Description	ABI family, member 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Chromosome	17
Cytoband	q21.32
Chromosome location (bp)	49210227 - 49223225
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108798 (version 83.38)
Entrez gene	51225
UniProt	Q9P2A4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P2A4
Antibodypedia	ABI3 antibodies

PROTEIN BROWSER

ABI3-001	ABI3-002	ABI3-003	ABI3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABI3-001 ENSP00000225941 ENST00000225941	Q9P2A4 [Direct mapping] ABI gene family member 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006928 [movement of cell or subcellular component] GO:0016020 [membrane] GO:0030027 [lamellipodium] GO:0030334 [regulation of cell migration] Show all	366 aa 39 kDa	No	0
ABI3-002 ENSP00000406651 ENST00000419580	Q9P2A4 [Direct mapping] ABI gene family member 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006928 [movement of cell or subcellular component] GO:0016020 [membrane] GO:0030027 [lamellipodium] GO:0030334 [regulation of cell migration] Show all	360 aa 38.4 kDa	No	0
ABI3-003 ENSP00000460776 ENST00000573347	I3L3W4 [Direct mapping] ABI gene family member 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		160 aa 16.1 kDa	No	0
ABI3-004 ENSP00000459171 ENST00000571035	I3L1X2 [Direct mapping] ABI gene family member 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	191 aa 19.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.