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Cancer tissues were mostly weakly to moderately stained in the cytoplasm. Isolated cases of malignant carcinoids and malignant glioma showed strong positivity. Stomach cancers were mainly weakly stained and lymphomas were mostly negative.
A majority of the malignant cells showed moderate cytoplasmic staining. Several colorectal as well as a few cases of ovarian cancers and cholangiocarcinomas displayed strong cytoplasmic and membranous positivity. Malignant lymphomas, renal, skin, urothelial and lung cancers were weakly stained or negative.
Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004052 [arachidonate 12-lipoxygenase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006928 [movement of cell or subcellular component] GO:0007568 [aging] GO:0008284 [positive regulation of cell proliferation] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0010656 [negative regulation of muscle cell apoptotic process] GO:0010942 [positive regulation of cell death] GO:0016020 [membrane] GO:0016165 [linoleate 13S-lipoxygenase activity] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0019369 [arachidonic acid metabolic process] GO:0019372 [lipoxygenase pathway] GO:0019395 [fatty acid oxidation] GO:0030307 [positive regulation of cell growth] GO:0030335 [positive regulation of cell migration] GO:0042383 [sarcolemma] GO:0042554 [superoxide anion generation] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043651 [linoleic acid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045603 [positive regulation of endothelial cell differentiation] GO:0045766 [positive regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045909 [positive regulation of vasodilation] GO:0046872 [metal ion binding] GO:0047977 [hepoxilin-epoxide hydrolase activity] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0051120 [hepoxilin A3 synthase activity] GO:0051121 [hepoxilin metabolic process] GO:0051122 [hepoxilin biosynthetic process] GO:0051901 [positive regulation of mitochondrial depolarization] GO:0055114 [oxidation-reduction process] GO:0061436 [establishment of skin barrier] GO:0070062 [extracellular exosome] GO:0071396 [cellular response to lipid] GO:0072593 [reactive oxygen species metabolic process] GO:0090331 [negative regulation of platelet aggregation] GO:1901751 [leukotriene A4 metabolic process] GO:2001300 [lipoxin metabolic process] GO:2001303 [lipoxin A4 biosynthetic process] GO:2001306 [lipoxin B4 biosynthetic process]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0005506 [iron ion binding] GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process]