Expression of LUC7L3 in cancer - Summary - The Human Protein Atlas

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LUC7L3

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LUC7L3
Gene description	LUC7-like 3 pre-mRNA splicing factor
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA018475 , HPA018484 , HPA020017
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), urothelial cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Urothelial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018475	HPA018484	HPA020017

GENE INFORMATION
Gene name	LUC7L3 (HGNC Symbol)
Synonyms	CRA, CREAP-1, CROP, FLJ11063, hLuc7A, LUC7A, OA48-18
Description	LUC7-like 3 pre-mRNA splicing factor (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2009]
Chromosome	17
Cytoband	q21.33
Chromosome location (bp)	50719544 - 50756213
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108848 (version 83.38)
Entrez gene	51747
UniProt	O95232 (UniProt - Evidence at protein level)
neXtProt	NX_O95232
Antibodypedia	LUC7L3 antibodies

PROTEIN BROWSER

LUC7L3-001	LUC7L3-002	LUC7L3-004	LUC7L3-011	LUC7L3-012	LUC7L3-021	LUC7L3-022	LUC7L3-025	LUC7L3-026	LUC7L3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LUC7L3-001 ENSP00000425092 ENST00000505658	O95232 [Direct mapping] Luc7-like protein 3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005685 [U1 snRNP] GO:0006376 [mRNA splice site selection] GO:0008380 [RNA splicing] GO:0016607 [nuclear speck] GO:0044822 [poly(A) RNA binding] GO:0071004 [U2-type prespliceosome] Show all	432 aa 51.5 kDa	No	0
LUC7L3-002 ENSP00000240304 ENST00000240304	O95232 [Direct mapping] Luc7-like protein 3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005685 [U1 snRNP] GO:0006376 [mRNA splice site selection] GO:0008380 [RNA splicing] GO:0016607 [nuclear speck] GO:0044822 [poly(A) RNA binding] GO:0071004 [U2-type prespliceosome] Show all	432 aa 51.5 kDa	No	0
LUC7L3-004 ENSP00000376919 ENST00000393227	J3KPP4 [Direct mapping] Cisplatin resistance-associated overexpressed protein, isoform CRA_b; Luc7-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003729 [mRNA binding] GO:0005654 [nucleoplasm] GO:0005685 [U1 snRNP] GO:0006376 [mRNA splice site selection] Show all	489 aa 58.2 kDa	No	0
LUC7L3-011 ENSP00000420933 ENST00000505619	D6RDI2 [Direct mapping] Luc7-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003729 [mRNA binding] GO:0005685 [U1 snRNP] GO:0006376 [mRNA splice site selection] Show all	184 aa 20.7 kDa	No	0
LUC7L3-012 ENSP00000426123 ENST00000510984	D6RHH0 [Direct mapping] Luc7-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003729 [mRNA binding] GO:0005685 [U1 snRNP] GO:0006376 [mRNA splice site selection] Show all	36 aa 4.3 kDa	No	0
LUC7L3-021 ENSP00000428225 ENST00000511974	H0YAX1 [Direct mapping] Luc7-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		86 aa 10.2 kDa	No	0
LUC7L3-022 ENSP00000427927 ENST00000513969	H0YAR4 [Direct mapping] Luc7-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003729 [mRNA binding] GO:0005685 [U1 snRNP] GO:0006376 [mRNA splice site selection] Show all	123 aa 14.4 kDa	No	0
LUC7L3-025 ENSP00000476198 ENST00000513025	U3KQT3 [Direct mapping] Luc7-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003729 [mRNA binding] GO:0005685 [U1 snRNP] GO:0006376 [mRNA splice site selection] Show all	47 aa 5.3 kDa	No	0
LUC7L3-026 ENSP00000430407 ENST00000503728	H0YBV7 [Direct mapping] Luc7-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003729 [mRNA binding] GO:0005685 [U1 snRNP] GO:0006376 [mRNA splice site selection] Show all	118 aa 13.3 kDa	No	0
LUC7L3-201 ENSP00000486238 ENST00000625349	C9JL41 [Direct mapping] Luc7-like protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003729 [mRNA binding] GO:0005685 [U1 snRNP] GO:0006376 [mRNA splice site selection] Show all	79 aa 9.3 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.