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Most malignancies were moderately stained. Strong immunoreactivity was observed in testicular cancers as well as few cases of colorectal, breast, pancreatic, urothelial and thyroid cancers.
A majority of malignant tissues displayed moderate to strong cytoplasmic and nuclear positivity. Malignant lymphomas and liver cancers were weakly stained or negative.
A majority of malignancies showed weak to moderate cytoplasmic positivity, combined with cases of nuclear staining.
Most malignant lymphomas as well as several lung, gastric and liver cancers were negative.
A majority of malignant cells showed weak to moderate cytoplasmic staining with additional nuclear positivity in many cases. Several cases of malignant lymphomas and liver cancers were negative.
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
P62258 [Direct mapping] 14-3-3 protein epsilon V9HW98 [Target identity:100%; Query identity:100%] Epididymis luminal protein 2
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Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0001764 [neuron migration] GO:0003064 [regulation of heart rate by hormone] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005871 [kinesin complex] GO:0005925 [focal adhesion] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006605 [protein targeting] GO:0006915 [apoptotic process] GO:0006996 [organelle organization] GO:0007264 [small GTPase mediated signal transduction] GO:0010467 [gene expression] GO:0012501 [programmed cell death] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0016032 [viral process] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0021762 [substantia nigra development] GO:0021766 [hippocampus development] GO:0021987 [cerebral cortex development] GO:0023026 [MHC class II protein complex binding] GO:0030424 [axon] GO:0030659 [cytoplasmic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0032403 [protein complex binding] GO:0034605 [cellular response to heat] GO:0035308 [negative regulation of protein dephosphorylation] GO:0035329 [hippo signaling] GO:0035556 [intracellular signal transduction] GO:0042470 [melanosome] GO:0042826 [histone deacetylase binding] GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044325 [ion channel binding] GO:0044822 [poly(A) RNA binding] GO:0046982 [protein heterodimerization activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050815 [phosphoserine binding] GO:0051219 [phosphoprotein binding] GO:0060306 [regulation of membrane repolarization] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] GO:0086013 [membrane repolarization during cardiac muscle cell action potential] GO:0086091 [regulation of heart rate by cardiac conduction] GO:0097190 [apoptotic signaling pathway] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900034 [regulation of cellular response to heat] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901016 [regulation of potassium ion transmembrane transporter activity] GO:1902309 [negative regulation of peptidyl-serine dephosphorylation]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0003064 [regulation of heart rate by hormone] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005925 [focal adhesion] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006996 [organelle organization] GO:0007264 [small GTPase mediated signal transduction] GO:0010467 [gene expression] GO:0012501 [programmed cell death] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0016032 [viral process] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0021762 [substantia nigra development] GO:0023026 [MHC class II protein complex binding] GO:0030659 [cytoplasmic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0034605 [cellular response to heat] GO:0035329 [hippo signaling] GO:0035556 [intracellular signal transduction] GO:0042470 [melanosome] GO:0042826 [histone deacetylase binding] GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044325 [ion channel binding] GO:0044822 [poly(A) RNA binding] GO:0046982 [protein heterodimerization activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050815 [phosphoserine binding] GO:0051219 [phosphoprotein binding] GO:0060306 [regulation of membrane repolarization] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] GO:0086013 [membrane repolarization during cardiac muscle cell action potential] GO:0086091 [regulation of heart rate by cardiac conduction] GO:0097190 [apoptotic signaling pathway] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900034 [regulation of cellular response to heat] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901016 [regulation of potassium ion transmembrane transporter activity] GO:1902309 [negative regulation of peptidyl-serine dephosphorylation]