Expression of CHIC2 in cancer - Summary - The Human Protein Atlas

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CHIC2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CHIC2
Gene description	Cysteine-rich hydrophobic domain 2
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with variable levels in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 1 antibody. HPA026782
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA026782

GENE INFORMATION
Gene name	CHIC2 (HGNC Symbol)
Synonyms	BTL
Description	Cysteine-rich hydrophobic domain 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the CHIC family of proteins. The encoded protein contains a cysteine-rich hydrophobic (CHIC) motif, and is localized to vesicular structures and the plasma membrane. This gene is associated with some cases of acute myeloid leukemia. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q12
Chromosome location (bp)	54009789 - 54064690
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109220 (version 83.38)
Entrez gene	26511
UniProt	Q9UKJ5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UKJ5
Antibodypedia	CHIC2 antibodies

PROTEIN BROWSER

CHIC2-001	CHIC2-003	CHIC2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHIC2-001 ENSP00000263921 ENST00000263921	Q9UKJ5 [Direct mapping] Cysteine-rich hydrophobic domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005622 [intracellular] GO:0005794 [Golgi apparatus] GO:0005798 [Golgi-associated vesicle] GO:0005886 [plasma membrane] GO:0006893 [Golgi to plasma membrane transport] GO:0008150 [biological_process] Show all	165 aa 19.3 kDa	No	1
CHIC2-003 ENSP00000425238 ENST00000512964	D6RDW7 [Direct mapping] Cysteine-rich hydrophobic domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0005622 [intracellular] GO:0005798 [Golgi-associated vesicle] GO:0005886 [plasma membrane] GO:0006893 [Golgi to plasma membrane transport] Show all	146 aa 16.8 kDa	No	1
CHIC2-005 ENSP00000421032 ENST00000510894	H0Y8H1 [Direct mapping] Cysteine-rich hydrophobic domain-containing protein 2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0005622 [intracellular] GO:0005798 [Golgi-associated vesicle] GO:0005886 [plasma membrane] GO:0006893 [Golgi to plasma membrane transport] Show all	137 aa 16 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.