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CHIC2

GENERAL INFORMATION

Gene name

 CHIC2

Gene description

 Cysteine-rich hydrophobic domain 2

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression with variable levels in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Uncertain based on 1 antibody.
HPA026782
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CHIC2 (HGNC Symbol)

Synonyms

 BTL

Description

 Cysteine-rich hydrophobic domain 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the CHIC family of proteins. The encoded protein contains a cysteine-rich hydrophobic (CHIC) motif, and is localized to vesicular structures and the plasma membrane. This gene is associated with some cases of acute myeloid leukemia. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q12

Chromosome location (bp)

 54009789 - 54064690

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109220 (version 83.38)

Entrez gene

 26511

UniProt

 Q9UKJ5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKJ5

Antibodypedia

 CHIC2 antibodies

PROTEIN BROWSER
CHIC2-001
CHIC2-003
CHIC2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHIC2-001
ENSP00000263921
ENST00000263921
Q9UKJ5 [Direct mapping]
Cysteine-rich hydrophobic domain-containing protein 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005798 [Golgi-associated vesicle]
GO:0005886 [plasma membrane]
GO:0006893 [Golgi to plasma membrane transport]
GO:0008150 [biological_process]
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 165 aa
19.3 kDa 		No 1
CHIC2-003
ENSP00000425238
ENST00000512964
D6RDW7 [Direct mapping]
Cysteine-rich hydrophobic domain-containing protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Show all
GO:0005622 [intracellular]
GO:0005798 [Golgi-associated vesicle]
GO:0005886 [plasma membrane]
GO:0006893 [Golgi to plasma membrane transport]
Show all
 146 aa
16.8 kDa 		No 1
CHIC2-005
ENSP00000421032
ENST00000510894
H0Y8H1 [Direct mapping]
Cysteine-rich hydrophobic domain-containing protein 2
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Show all
GO:0005622 [intracellular]
GO:0005798 [Golgi-associated vesicle]
GO:0005886 [plasma membrane]
GO:0006893 [Golgi to plasma membrane transport]
Show all
 137 aa
16 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.