Expression of TBC1D9 in cancer - Summary - The Human Protein Atlas

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TBC1D9

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TBC1D9
Gene description	TBC1 domain family, member 9 (with GRAM domain)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (breast cancer)
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA000262 , HPA006503
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (breast cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000262	HPA006503

GENE INFORMATION
Gene name	TBC1D9 (HGNC Symbol)
Synonyms	KIAA0882, MDR1
Description	TBC1 domain family, member 9 (with GRAM domain) (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q31.21
Chromosome location (bp)	140620765 - 140756120
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109436 (version 83.38)
Entrez gene	23158
UniProt	Q6ZT07 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6ZT07
Antibodypedia	TBC1D9 antibodies

PROTEIN BROWSER

TBC1D9-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBC1D9-001 ENSP00000411197 ENST00000442267	Q6ZT07 [Direct mapping] TBC1 domain family member 9 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0043547 [positive regulation of GTPase activity] Show all	1266 aa 143.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.