Expression of TRIM2 in cancer - Summary - The Human Protein Atlas

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TRIM2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TRIM2
Gene description	Tripartite motif containing 2
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (AF22, NTERA-2)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression mainly in the CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA035853 , HPA035854
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035853	HPA035854

GENE INFORMATION
Gene name	TRIM2 (HGNC Symbol)
Synonyms	CMT2R, KIAA0517, RNF86
Description	Tripartite motif containing 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Chromosome	4
Cytoband	q31.3
Chromosome location (bp)	153152342 - 153339320
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109654 (version 83.38)
Entrez gene	23321
UniProt	Q9C040 (UniProt - Evidence at protein level)
neXtProt	NX_Q9C040
Antibodypedia	TRIM2 antibodies

PROTEIN BROWSER

TRIM2-001	TRIM2-002	TRIM2-004	TRIM2-005	TRIM2-006	TRIM2-010	TRIM2-011	TRIM2-013	TRIM2-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRIM2-001 ENSP00000339659 ENST00000338700	Q9C040 [Direct mapping] Tripartite motif-containing protein 2 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0043523 [regulation of neuron apoptotic process] GO:0061630 [ubiquitin protein ligase activity] Show all	771 aa 84.5 kDa	No	0
TRIM2-002 ENSP00000487750 ENST00000482578		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	136 aa 14.8 kDa	No	0
TRIM2-004 ENSP00000415812 ENST00000437508	Q9C040 [Direct mapping] Tripartite motif-containing protein 2 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0043523 [regulation of neuron apoptotic process] Show all	744 aa 81.5 kDa	No	0
TRIM2-005 ENSP00000488229 ENST00000494872		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] Show all	526 aa 58.5 kDa	No	0
TRIM2-006 ENSP00000400879 ENST00000441616	C9JVI3 [Direct mapping] Tripartite motif-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] Show all	138 aa 15.2 kDa	No	0
TRIM2-010 ENSP00000400375 ENST00000433687	C9J084 [Direct mapping] Tripartite motif-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0008270 [zinc ion binding] Show all	110 aa 12.1 kDa	No	0
TRIM2-011 ENSP00000488751 ENST00000460908		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	114 aa 12.3 kDa	No	0
TRIM2-013 ENSP00000488602 ENST00000502281		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046872 [metal ion binding] Show all	44 aa 5 kDa	No	0
TRIM2-014 ENSP00000487836 ENST00000632856		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	136 aa 14.8 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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