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TRIM2

GENERAL INFORMATION

Gene name

 TRIM2

Gene description

 Tripartite motif containing 2

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in the CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA035853 , HPA035854
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Caudate

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TRIM2 (HGNC Symbol)

Synonyms

 CMT2R, KIAA0517, RNF86

Description

 Tripartite motif containing 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Chromosome

 4

Cytoband

 q31.3

Chromosome location (bp)

 153152342 - 153339320

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109654 (version 83.38)

Entrez gene

 23321

UniProt

 Q9C040 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9C040

Antibodypedia

 TRIM2 antibodies

PROTEIN BROWSER
TRIM2-001
TRIM2-002
TRIM2-004
TRIM2-005
TRIM2-006
TRIM2-010
TRIM2-011
TRIM2-013
TRIM2-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRIM2-001
ENSP00000339659
ENST00000338700
Q9C040 [Direct mapping]
Tripartite motif-containing protein 2
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0043523 [regulation of neuron apoptotic process]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 771 aa
84.5 kDa 		No 0
TRIM2-002
ENSP00000487750
ENST00000482578
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 136 aa
14.8 kDa 		No 0
TRIM2-004
ENSP00000415812
ENST00000437508
Q9C040 [Direct mapping]
Tripartite motif-containing protein 2
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0043523 [regulation of neuron apoptotic process]
Show all
 744 aa
81.5 kDa 		No 0
TRIM2-005
ENSP00000488229
ENST00000494872
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0008270 [zinc ion binding]
Show all
 526 aa
58.5 kDa 		No 0
TRIM2-006
ENSP00000400879
ENST00000441616
C9JVI3 [Direct mapping]
Tripartite motif-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0008270 [zinc ion binding]
Show all
 138 aa
15.2 kDa 		No 0
TRIM2-010
ENSP00000400375
ENST00000433687
C9J084 [Direct mapping]
Tripartite motif-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0008270 [zinc ion binding]
Show all
 110 aa
12.1 kDa 		No 0
TRIM2-011
ENSP00000488751
ENST00000460908
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 114 aa
12.3 kDa 		No 0
TRIM2-013
ENSP00000488602
ENST00000502281
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046872 [metal ion binding]
Show all
 44 aa
5 kDa 		No 0
TRIM2-014
ENSP00000487836
ENST00000632856
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 136 aa
14.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.