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BST1

GENERAL INFORMATION

Gene name

 BST1

Gene description

 Bone marrow stromal cell antigen 1

Protein class

 CD markers
Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (bone marrow)
GTEx:Mixed
FANTOM5:Tissue enhanced (small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in selected tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA050121
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine)

GENE INFORMATION

Gene name

 BST1 (HGNC Symbol)

Synonyms

 CD157

Description

 Bone marrow stromal cell antigen 1 (HGNC Symbol)

Entrez gene summary

 Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p15.32

Chromosome location (bp)

 15702950 - 15738313

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109743 (version 83.38)

Entrez gene

 683

UniProt

 Q10588 (UniProt - Evidence at protein level)

neXtProt

 NX_Q10588

Antibodypedia

 BST1 antibodies

PROTEIN BROWSER
BST1-001
BST1-002
BST1-003
BST1-004
BST1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BST1-001
ENSP00000265016
ENST00000265016
Q10588 [Direct mapping]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
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Enzymes
   ENZYME proteins
   Hydrolases
CD markers
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003953 [NAD+ nucleosidase activity]
GO:0005886 [plasma membrane]
GO:0006959 [humoral immune response]
GO:0007275 [multicellular organismal development]
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0019898 [extrinsic component of membrane]
GO:0030890 [positive regulation of B cell proliferation]
GO:0031225 [anchored component of membrane]
GO:0050135 [NAD(P)+ nucleosidase activity]
GO:0070062 [extracellular exosome]
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 318 aa
35.7 kDa 		Yes 0
BST1-002
ENSP00000371783
ENST00000382346
A6NC48 [Direct mapping]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003953 [NAD+ nucleosidase activity]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0030890 [positive regulation of B cell proliferation]
Show all
 333 aa
37.5 kDa 		Yes 0
BST1-003
ENSP00000424761
ENST00000514989
H0Y9Q9 [Direct mapping]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003953 [NAD+ nucleosidase activity]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0030890 [positive regulation of B cell proliferation]
Show all
 97 aa
11 kDa 		No 0
BST1-004
ENSP00000423357
ENST00000505785
H0Y984 [Direct mapping]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003953 [NAD+ nucleosidase activity]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0030890 [positive regulation of B cell proliferation]
Show all
 186 aa
21 kDa 		No 0
BST1-005
ENSP00000420925
ENST00000514445
H0Y8G4 [Direct mapping]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003953 [NAD+ nucleosidase activity]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0030890 [positive regulation of B cell proliferation]
Show all
 155 aa
17.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.