Cell atlas - MS4A6A - The Human Protein Atlas

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MS4A6A

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	MS4A6A
Gene description	Membrane-spanning 4-domains, subfamily A, member 6A
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enriched (THP-1)
Protein evidence	Evidence at transcript level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA076623
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (THP-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA076623	HUVEC TERT2	Vesicles

GENE INFORMATION
Gene name	MS4A6A (HGNC Symbol)
Synonyms	CD20L3, MS4A6
Description	Membrane-spanning 4-domains, subfamily A, member 6A (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.1, among a cluster of family members. Alternative splicing of this gene results in several transcript variants that encode different protein isoforms. [provided by RefSeq, Oct 2011]
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	60172014 - 60184666
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000110077 (version 83.38)
Entrez gene	64231
UniProt	Q9H2W1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H2W1
Antibodypedia	MS4A6A antibodies

PROTEIN BROWSER

MS4A6A-001	MS4A6A-002	MS4A6A-003	MS4A6A-004	MS4A6A-005	MS4A6A-006	MS4A6A-009	MS4A6A-013	MS4A6A-014	MS4A6A-016	MS4A6A-018	MS4A6A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MS4A6A-001 ENSP00000436979 ENST00000530839	Q9H2W1 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A A0A024R554 [Target identity:100%; Query identity:100%] Membrane-spanning 4-domains, subfamily A, member 6A, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0051726 [regulation of cell cycle] Show all	248 aa 26.9 kDa	No	4
MS4A6A-002 ENSP00000431901 ENST00000528851	Q9H2W1 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A A0A024R516 [Target identity:100%; Query identity:100%] Membrane-spanning 4-domains, subfamily A, member 6A, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0051726 [regulation of cell cycle] Show all	225 aa 24.3 kDa	No	4
MS4A6A-003 ENSP00000392921 ENST00000420732	Q9H2W1 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0051726 [regulation of cell cycle] Show all	178 aa 18.8 kDa	No	3
MS4A6A-004 ENSP00000435844 ENST00000529054	E9PSA9 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0051726 [regulation of cell cycle] Show all	276 aa 30 kDa	No	4
MS4A6A-005 ENSP00000431266 ENST00000532169	Q9H2W1 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0051726 [regulation of cell cycle] Show all	141 aa 15.1 kDa	No	1
MS4A6A-006 ENSP00000403212 ENST00000412309	Q9H2W1 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0051726 [regulation of cell cycle] Show all	253 aa 27.4 kDa	No	4
MS4A6A-009 ENSP00000437152 ENST00000533409	E9PNG6 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A Show all	Predicted intracellular proteins Show all		23 aa 2.5 kDa	No	0
MS4A6A-013 ENSP00000433436 ENST00000534596	E9PL03 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0051726 [regulation of cell cycle] Show all	101 aa 10.9 kDa	No	1
MS4A6A-014 ENSP00000436172 ENST00000533023	G5EA21 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A; Membrane-spanning 4-domains, subfamily A, member 6A, isoform CRA_c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	114 aa 11.9 kDa	No	1
MS4A6A-016 ENSP00000433012 ENST00000531531	E9PMN8 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A Show all	Predicted intracellular proteins Show all		77 aa 8.5 kDa	No	0
MS4A6A-018 ENSP00000436133 ENST00000533989	H0YEM2 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0051726 [regulation of cell cycle] Show all	113 aa 11.7 kDa	No	1
MS4A6A-201 ENSP00000392770 ENST00000426738	Q9H2W1 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0051726 [regulation of cell cycle] Show all	253 aa 27.4 kDa	No	4

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.