Expression of MS4A6A in cancer - Summary - The Human Protein Atlas

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MS4A6A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MS4A6A
Gene description	Membrane-spanning 4-domains, subfamily A, member 6A
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (THP-1)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 1 antibody. HPA011391
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011391

GENE INFORMATION
Gene name	MS4A6A (HGNC Symbol)
Synonyms	CD20L3, MS4A6
Description	Membrane-spanning 4-domains, subfamily A, member 6A (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.1, among a cluster of family members. Alternative splicing of this gene results in several transcript variants that encode different protein isoforms. [provided by RefSeq, Oct 2011]
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	60172014 - 60184666
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000110077 (version 83.38)
Entrez gene	64231
UniProt	Q9H2W1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H2W1
Antibodypedia	MS4A6A antibodies

PROTEIN BROWSER

MS4A6A-001	MS4A6A-002	MS4A6A-003	MS4A6A-004	MS4A6A-005	MS4A6A-006	MS4A6A-009	MS4A6A-013	MS4A6A-014	MS4A6A-016	MS4A6A-018	MS4A6A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MS4A6A-001 ENSP00000436979 ENST00000530839	Q9H2W1 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A A0A024R554 [Target identity:100%; Query identity:100%] Membrane-spanning 4-domains, subfamily A, member 6A, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0051726 [regulation of cell cycle] Show all	248 aa 26.9 kDa	No	4
MS4A6A-002 ENSP00000431901 ENST00000528851	Q9H2W1 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A A0A024R516 [Target identity:100%; Query identity:100%] Membrane-spanning 4-domains, subfamily A, member 6A, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0051726 [regulation of cell cycle] Show all	225 aa 24.3 kDa	No	4
MS4A6A-003 ENSP00000392921 ENST00000420732	Q9H2W1 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0051726 [regulation of cell cycle] Show all	178 aa 18.8 kDa	No	3
MS4A6A-004 ENSP00000435844 ENST00000529054	E9PSA9 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0051726 [regulation of cell cycle] Show all	276 aa 30 kDa	No	4
MS4A6A-005 ENSP00000431266 ENST00000532169	Q9H2W1 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0051726 [regulation of cell cycle] Show all	141 aa 15.1 kDa	No	1
MS4A6A-006 ENSP00000403212 ENST00000412309	Q9H2W1 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0051726 [regulation of cell cycle] Show all	253 aa 27.4 kDa	No	4
MS4A6A-009 ENSP00000437152 ENST00000533409	E9PNG6 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A Show all	Predicted intracellular proteins Show all		23 aa 2.5 kDa	No	0
MS4A6A-013 ENSP00000433436 ENST00000534596	E9PL03 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0051726 [regulation of cell cycle] Show all	101 aa 10.9 kDa	No	1
MS4A6A-014 ENSP00000436172 ENST00000533023	G5EA21 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A; Membrane-spanning 4-domains, subfamily A, member 6A, isoform CRA_c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	114 aa 11.9 kDa	No	1
MS4A6A-016 ENSP00000433012 ENST00000531531	E9PMN8 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A Show all	Predicted intracellular proteins Show all		77 aa 8.5 kDa	No	0
MS4A6A-018 ENSP00000436133 ENST00000533989	H0YEM2 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0051726 [regulation of cell cycle] Show all	113 aa 11.7 kDa	No	1
MS4A6A-201 ENSP00000392770 ENST00000426738	Q9H2W1 [Direct mapping] Membrane-spanning 4-domains subfamily A member 6A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0051726 [regulation of cell cycle] Show all	253 aa 27.4 kDa	No	4

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The Human Protein Atlas

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