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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CCND1
  • TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CCND1

Gene description

Cyclin D1

Protein class

Cancer-related genes
Disease related genes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (WM-115)
HPA (normal tissue):Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending retesting.

Reliability score

Uncertain based on 1 antibody.
CAB000024
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PROGNOSTIC SUMMARY

Prognostic marker in pancreatic cancer (unfavourable) and head and neck cancer (unfavourable).
Pancreatic cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB000024

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few cases of melanoma, liver, renal, urothelial and prostate cancers showed moderate to strong immunoreactivity. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

CCND1 (HGNC Symbol)

Synonyms

BCL1, D11S287E, PRAD1, U21B31

Description

Cyclin D1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q13.3

Chromosome location (bp)

69641087 - 69654474

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000110092 (version 83.38)

Entrez gene

595

UniProt

P24385 (UniProt - Evidence at protein level)

neXtProt

NX_P24385

Antibodypedia

CCND1 antibodies

PROTEIN BROWSER

CCND1-001
CCND1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCND1-001
ENSP00000227507
ENST00000227507
P24385 [Direct mapping]
G1/S-specific cyclin-D1
Q6FI00 [Target identity:100%; Query identity:100%]
CCND1 protein; Cyclin D1 (PRAD1: parathyroid adenomatosis 1); Cyclin D1, isoform CRA_c; cDNA, FLJ93625, Homo sapiens cyclin D1 (PRAD1: parathyroid adenomatosis 1) (CCND1),mRNA
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000278 [mitotic cell cycle]
GO:0000307 [cyclin-dependent protein kinase holoenzyme complex]
GO:0000320 [re-entry into mitotic cell cycle]
GO:0001889 [liver development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003714 [transcription corepressor activity]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005923 [bicellular tight junction]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007219 [Notch signaling pathway]
GO:0007595 [lactation]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0010033 [response to organic substance]
GO:0010039 [response to iron ion]
GO:0010165 [response to X-ray]
GO:0010243 [response to organonitrogen compound]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016301 [kinase activity]
GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity]
GO:0017053 [transcriptional repressor complex]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030857 [negative regulation of epithelial cell differentiation]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031100 [organ regeneration]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0032026 [response to magnesium ion]
GO:0032355 [response to estradiol]
GO:0032403 [protein complex binding]
GO:0033197 [response to vitamin E]
GO:0033327 [Leydig cell differentiation]
GO:0033598 [mammary gland epithelial cell proliferation]
GO:0033601 [positive regulation of mammary gland epithelial cell proliferation]
GO:0042493 [response to drug]
GO:0042826 [histone deacetylase binding]
GO:0043627 [response to estrogen]
GO:0045444 [fat cell differentiation]
GO:0045471 [response to ethanol]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0048545 [response to steroid hormone]
GO:0051301 [cell division]
GO:0051384 [response to glucocorticoid]
GO:0051412 [response to corticosterone]
GO:0051592 [response to calcium ion]
GO:0051726 [regulation of cell cycle]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060749 [mammary gland alveolus development]
GO:0070064 [proline-rich region binding]
GO:0070141 [response to UV-A]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0071310 [cellular response to organic substance]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
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295 aa
33.7 kDa
No 0
CCND1-004
ENSP00000438482
ENST00000536559
F5H437 [Direct mapping]
G1/S-specific cyclin-D1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007049 [cell cycle]
Show all
67 aa
7.8 kDa
No 0

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