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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CCND1
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CCND1

Gene description

Cyclin D1

Protein class

Cancer-related genes
Disease related genes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (parathyroid gland)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and nuclear expression in several tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending retesting.

Reliability score

Uncertain based on 1 antibody.
CAB000024
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

CCND1 (HGNC Symbol)

Synonyms

BCL1, D11S287E, PRAD1, U21B31

Description

Cyclin D1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q13.3

Chromosome location (bp)

69641087 - 69654474

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000110092 (version 83.38)

Entrez gene

595

UniProt

P24385 (UniProt - Evidence at protein level)

neXtProt

NX_P24385

Antibodypedia

CCND1 antibodies

PROTEIN BROWSER

CCND1-001
CCND1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCND1-001
ENSP00000227507
ENST00000227507
P24385 [Direct mapping]
G1/S-specific cyclin-D1
Q6FI00 [Target identity:100%; Query identity:100%]
CCND1 protein; Cyclin D1 (PRAD1: parathyroid adenomatosis 1); Cyclin D1, isoform CRA_c; cDNA, FLJ93625, Homo sapiens cyclin D1 (PRAD1: parathyroid adenomatosis 1) (CCND1),mRNA
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000278 [mitotic cell cycle]
GO:0000307 [cyclin-dependent protein kinase holoenzyme complex]
GO:0000320 [re-entry into mitotic cell cycle]
GO:0001889 [liver development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003714 [transcription corepressor activity]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005923 [bicellular tight junction]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007219 [Notch signaling pathway]
GO:0007595 [lactation]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0010033 [response to organic substance]
GO:0010039 [response to iron ion]
GO:0010165 [response to X-ray]
GO:0010243 [response to organonitrogen compound]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016301 [kinase activity]
GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity]
GO:0017053 [transcriptional repressor complex]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030857 [negative regulation of epithelial cell differentiation]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031100 [organ regeneration]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0032026 [response to magnesium ion]
GO:0032355 [response to estradiol]
GO:0032403 [protein complex binding]
GO:0033197 [response to vitamin E]
GO:0033327 [Leydig cell differentiation]
GO:0033598 [mammary gland epithelial cell proliferation]
GO:0033601 [positive regulation of mammary gland epithelial cell proliferation]
GO:0042493 [response to drug]
GO:0042826 [histone deacetylase binding]
GO:0043627 [response to estrogen]
GO:0045444 [fat cell differentiation]
GO:0045471 [response to ethanol]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0048545 [response to steroid hormone]
GO:0051301 [cell division]
GO:0051384 [response to glucocorticoid]
GO:0051412 [response to corticosterone]
GO:0051592 [response to calcium ion]
GO:0051726 [regulation of cell cycle]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060749 [mammary gland alveolus development]
GO:0070064 [proline-rich region binding]
GO:0070141 [response to UV-A]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0071310 [cellular response to organic substance]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
Show all
295 aa
33.7 kDa
No 0
CCND1-004
ENSP00000438482
ENST00000536559
F5H437 [Direct mapping]
G1/S-specific cyclin-D1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007049 [cell cycle]
Show all
67 aa
7.8 kDa
No 0

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