Expression of CCKBR in cancer - Summary - The Human Protein Atlas

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CCKBR

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	CCKBR
Gene description	Cholecystokinin B receptor
Protein class	Cancer-related genes FDA approved drug targets G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (testis cancer)
HPA (cell line):	Cell line enriched (NTERA-2)
HPA (normal tissue):	Group enriched (cerebral cortex, pancreas, stomach)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	CCKBR
Synonyms
Description	Cholecystokinin B receptor (HGNC Symbol)
Entrez gene summary	This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	6259736 - 6272127
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110148 (version 83.38)
Entrez gene	887
UniProt	P32239 (UniProt - Evidence at protein level)
neXtProt	NX_P32239
Antibodypedia	CCKBR antibodies

PROTEIN BROWSER

CCKBR-001	CCKBR-002	CCKBR-003	CCKBR-004	CCKBR-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCKBR-001 ENSP00000335544 ENST00000334619	P32239 [Direct mapping] Gastrin/cholecystokinin type B receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Show all	GO:0001696 [gastric acid secretion] GO:0004435 [phosphatidylinositol phospholipase C activity] GO:0004930 [G-protein coupled receptor activity] GO:0004951 [cholecystokinin receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007586 [digestion] GO:0007600 [sensory perception] GO:0007631 [feeding behavior] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0015054 [gastrin receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031741 [type B gastrin/cholecystokinin receptor binding] GO:0038188 [cholecystokinin signaling pathway] GO:0043551 [regulation of phosphatidylinositol 3-kinase activity] GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity] GO:0048565 [digestive tract development] GO:0048732 [gland development] Show all	447 aa 48.4 kDa	No	7
CCKBR-002 ENSP00000435675 ENST00000531712	E9PJ49 [Direct mapping] Gastrin/cholecystokinin type B receptor Show all	Predicted intracellular proteins Show all	GO:0007186 [G-protein coupled receptor signaling pathway] GO:0015054 [gastrin receptor activity] GO:0016021 [integral component of membrane] Show all	87 aa 9.4 kDa	No	0
CCKBR-003 ENSP00000435534 ENST00000525462	P32239 [Direct mapping] Gastrin/cholecystokinin type B receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Show all	GO:0004435 [phosphatidylinositol phospholipase C activity] GO:0004930 [G-protein coupled receptor activity] GO:0004951 [cholecystokinin receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007586 [digestion] GO:0007600 [sensory perception] GO:0007631 [feeding behavior] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0015054 [gastrin receptor activity] GO:0016021 [integral component of membrane] GO:0031741 [type B gastrin/cholecystokinin receptor binding] GO:0038188 [cholecystokinin signaling pathway] GO:0043551 [regulation of phosphatidylinositol 3-kinase activity] GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity] Show all	516 aa 55.9 kDa	No	7
CCKBR-004 ENSP00000432079 ENST00000532715	E9PIC8 [Direct mapping] Gastrin/cholecystokinin type B receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0015054 [gastrin receptor activity] GO:0016021 [integral component of membrane] Show all	363 aa 39.3 kDa	No	5
CCKBR-007 ENSP00000437001 ENST00000525014	E9PPL7 [Direct mapping] Gastrin/cholecystokinin type B receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0015054 [gastrin receptor activity] GO:0016021 [integral component of membrane] Show all	136 aa 14.3 kDa	No	3

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