Tissue expression of CCKBR - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CCKBR
Gene description	Cholecystokinin B receptor
Protein class	Cancer-related genes FDA approved drug targets G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (cerebral cortex, pancreas, stomach)
GTEx:	Tissue enhanced (cerebellum, cerebral cortex, stomach)
FANTOM5:	Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebral cortex, pancreas, stomach)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum, cerebral cortex, stomach)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pancreas)

GENE INFORMATION
Gene name	CCKBR
Synonyms
Description	Cholecystokinin B receptor (HGNC Symbol)
Entrez gene summary	This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	6259736 - 6272127
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110148 (version 83.38)
Entrez gene	887
UniProt	P32239 (UniProt - Evidence at protein level)
neXtProt	NX_P32239
Antibodypedia	CCKBR antibodies

PROTEIN BROWSER

CCKBR-001	CCKBR-002	CCKBR-003	CCKBR-004	CCKBR-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCKBR-001 ENSP00000335544 ENST00000334619	P32239 [Direct mapping] Gastrin/cholecystokinin type B receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Show all	GO:0001696 [gastric acid secretion] GO:0004435 [phosphatidylinositol phospholipase C activity] GO:0004930 [G-protein coupled receptor activity] GO:0004951 [cholecystokinin receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007586 [digestion] GO:0007600 [sensory perception] GO:0007631 [feeding behavior] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0015054 [gastrin receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031741 [type B gastrin/cholecystokinin receptor binding] GO:0038188 [cholecystokinin signaling pathway] GO:0043551 [regulation of phosphatidylinositol 3-kinase activity] GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity] GO:0048565 [digestive tract development] GO:0048732 [gland development] Show all	447 aa 48.4 kDa	No	7
CCKBR-002 ENSP00000435675 ENST00000531712	E9PJ49 [Direct mapping] Gastrin/cholecystokinin type B receptor Show all	Predicted intracellular proteins Show all	GO:0007186 [G-protein coupled receptor signaling pathway] GO:0015054 [gastrin receptor activity] GO:0016021 [integral component of membrane] Show all	87 aa 9.4 kDa	No	0
CCKBR-003 ENSP00000435534 ENST00000525462	P32239 [Direct mapping] Gastrin/cholecystokinin type B receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Show all	GO:0004435 [phosphatidylinositol phospholipase C activity] GO:0004930 [G-protein coupled receptor activity] GO:0004951 [cholecystokinin receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007586 [digestion] GO:0007600 [sensory perception] GO:0007631 [feeding behavior] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0015054 [gastrin receptor activity] GO:0016021 [integral component of membrane] GO:0031741 [type B gastrin/cholecystokinin receptor binding] GO:0038188 [cholecystokinin signaling pathway] GO:0043551 [regulation of phosphatidylinositol 3-kinase activity] GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity] Show all	516 aa 55.9 kDa	No	7
CCKBR-004 ENSP00000432079 ENST00000532715	E9PIC8 [Direct mapping] Gastrin/cholecystokinin type B receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0015054 [gastrin receptor activity] GO:0016021 [integral component of membrane] Show all	363 aa 39.3 kDa	No	5
CCKBR-007 ENSP00000437001 ENST00000525014	E9PPL7 [Direct mapping] Gastrin/cholecystokinin type B receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0015054 [gastrin receptor activity] GO:0016021 [integral component of membrane] Show all	136 aa 14.3 kDa	No	3