Cell atlas - ARHGEF17 - The Human Protein Atlas

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ARHGEF17

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	ARHGEF17
Gene description	Rho guanine nucleotide exchange factor (GEF) 17
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA007991
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA007991	A-431	Cytosol
	HPA007991	U-2 OS	No staining
	HPA007991	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ARHGEF17 (HGNC Symbol)
Synonyms	KIAA0337, p164-RhoGEF, TEM4
Description	Rho guanine nucleotide exchange factor (GEF) 17 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q13.4
Chromosome location (bp)	73308289 - 73369091
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110237 (version 83.38)
Entrez gene	9828
UniProt	Q96PE2 (UniProt - Evidence at protein level)
neXtProt	NX_Q96PE2
Antibodypedia	ARHGEF17 antibodies

PROTEIN BROWSER

ARHGEF17-001	ARHGEF17-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGEF17-001 ENSP00000263674 ENST00000263674	Q96PE2 [Direct mapping] Rho guanine nucleotide exchange factor 17 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0030036 [actin cytoskeleton organization] GO:0035023 [regulation of Rho protein signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0043547 [positive regulation of GTPase activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0097190 [apoptotic signaling pathway] Show all	2063 aa 221.7 kDa	No	0
ARHGEF17-002 ENSP00000441135 ENST00000544519	H0YFZ8 [Direct mapping] Rho guanine nucleotide exchange factor 17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	193 aa 20.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.