Expression of ARHGEF17 in cancer - Summary - The Human Protein Atlas

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ARHGEF17

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ARHGEF17
Gene description	Rho guanine nucleotide exchange factor (GEF) 17
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA007991
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable).
Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007991

GENE INFORMATION
Gene name	ARHGEF17 (HGNC Symbol)
Synonyms	KIAA0337, p164-RhoGEF, TEM4
Description	Rho guanine nucleotide exchange factor (GEF) 17 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q13.4
Chromosome location (bp)	73308289 - 73369091
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110237 (version 83.38)
Entrez gene	9828
UniProt	Q96PE2 (UniProt - Evidence at protein level)
neXtProt	NX_Q96PE2
Antibodypedia	ARHGEF17 antibodies

PROTEIN BROWSER

ARHGEF17-001	ARHGEF17-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGEF17-001 ENSP00000263674 ENST00000263674	Q96PE2 [Direct mapping] Rho guanine nucleotide exchange factor 17 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0030036 [actin cytoskeleton organization] GO:0035023 [regulation of Rho protein signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0043547 [positive regulation of GTPase activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0097190 [apoptotic signaling pathway] Show all	2063 aa 221.7 kDa	No	0
ARHGEF17-002 ENSP00000441135 ENST00000544519	H0YFZ8 [Direct mapping] Rho guanine nucleotide exchange factor 17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	193 aa 20.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.