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BIRC2

GENERAL INFORMATION

Gene name

 BIRC2

Gene description

 Baculoviral IAP repeat containing 2

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression at variable levels in most cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA005513 , CAB020661
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005513
CAB020661

GENE INFORMATION

Gene name

 BIRC2 (HGNC Symbol)

Synonyms

 API1, c-IAP1, cIAP1, hiap-2, MIHB, RNF48

Description

 Baculoviral IAP repeat containing 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 11

Cytoband

 q22.2

Chromosome location (bp)

 102347211 - 102378670

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110330 (version 83.38)

Entrez gene

 329

UniProt

 Q13490 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13490

Antibodypedia

 BIRC2 antibodies

PROTEIN BROWSER
BIRC2-001
BIRC2-002
BIRC2-003
BIRC2-006
BIRC2-008
BIRC2-009
BIRC2-010
BIRC2-201
BIRC2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BIRC2-001
ENSP00000227758
ENST00000227758
Q13490 [Direct mapping]
Baculoviral IAP repeat-containing protein 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003713 [transcription coactivator activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008270 [zinc ion binding]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0016874 [ligase activity]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034121 [regulation of toll-like receptor signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035631 [CD40 receptor complex]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0039535 [regulation of RIG-I signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0045595 [regulation of cell differentiation]
GO:0047485 [protein N-terminus binding]
GO:0050727 [regulation of inflammatory response]
GO:0051726 [regulation of cell cycle]
GO:0060544 [regulation of necroptotic process]
GO:0060546 [negative regulation of necroptotic process]
GO:0070266 [necroptotic process]
GO:0070424 [regulation of nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:1902523 [positive regulation of protein K63-linked ubiquitination]
GO:1902524 [positive regulation of protein K48-linked ubiquitination]
GO:1902527 [positive regulation of protein monoubiquitination]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
GO:2000116 [regulation of cysteine-type endopeptidase activity]
Show all
 618 aa
69.9 kDa 		No 0
BIRC2-002
ENSP00000431723
ENST00000530675
Q13490 [Direct mapping]
Baculoviral IAP repeat-containing protein 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003713 [transcription coactivator activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008270 [zinc ion binding]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0016874 [ligase activity]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034121 [regulation of toll-like receptor signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035631 [CD40 receptor complex]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0039535 [regulation of RIG-I signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0045595 [regulation of cell differentiation]
GO:0047485 [protein N-terminus binding]
GO:0050727 [regulation of inflammatory response]
GO:0051726 [regulation of cell cycle]
GO:0060544 [regulation of necroptotic process]
GO:0060546 [negative regulation of necroptotic process]
GO:0070266 [necroptotic process]
GO:0070424 [regulation of nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:1902523 [positive regulation of protein K63-linked ubiquitination]
GO:1902524 [positive regulation of protein K48-linked ubiquitination]
GO:1902527 [positive regulation of protein monoubiquitination]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
GO:2000116 [regulation of cysteine-type endopeptidase activity]
Show all
 569 aa
64.1 kDa 		No 0
BIRC2-003
ENSP00000434979
ENST00000532672
E9PMH5 [Direct mapping]
Baculoviral IAP repeat-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0042981 [regulation of apoptotic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0060546 [negative regulation of necroptotic process]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 597 aa
67.5 kDa 		No 0
BIRC2-006
ENSP00000432410
ENST00000532832
E9PQZ9 [Direct mapping]
Baculoviral IAP repeat-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0060546 [negative regulation of necroptotic process]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 79 aa
8.9 kDa 		No 0
BIRC2-008
ENSP00000433851
ENST00000533742
E9PIW1 [Direct mapping]
Baculoviral IAP repeat-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0042981 [regulation of apoptotic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0060546 [negative regulation of necroptotic process]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 183 aa
20.5 kDa 		No 0
BIRC2-009
ENSP00000436741
ENST00000531259
E9PI77 [Direct mapping]
Baculoviral IAP repeat-containing protein 2
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0042981 [regulation of apoptotic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0060546 [negative regulation of necroptotic process]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 139 aa
15.8 kDa 		No 0
BIRC2-010
ENSP00000434708
ENST00000527465
E9PNM6 [Direct mapping]
Baculoviral IAP repeat-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0060546 [negative regulation of necroptotic process]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 149 aa
16.6 kDa 		No 0
BIRC2-201
ENSP00000477613
ENST00000613397
Q13490 [Direct mapping]
Baculoviral IAP repeat-containing protein 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0001666 [response to hypoxia]
GO:0001741 [XY body]
GO:0001890 [placenta development]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003713 [transcription coactivator activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008270 [zinc ion binding]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010243 [response to organonitrogen compound]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0014070 [response to organic cyclic compound]
GO:0016874 [ligase activity]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034121 [regulation of toll-like receptor signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035631 [CD40 receptor complex]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0039535 [regulation of RIG-I signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0045088 [regulation of innate immune response]
GO:0045121 [membrane raft]
GO:0045471 [response to ethanol]
GO:0045595 [regulation of cell differentiation]
GO:0047485 [protein N-terminus binding]
GO:0050727 [regulation of inflammatory response]
GO:0051291 [protein heterooligomerization]
GO:0051591 [response to cAMP]
GO:0051726 [regulation of cell cycle]
GO:0060544 [regulation of necroptotic process]
GO:0060546 [negative regulation of necroptotic process]
GO:0070266 [necroptotic process]
GO:0070424 [regulation of nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:1902443 [negative regulation of ripoptosome assembly involved in necroptotic process]
GO:1902523 [positive regulation of protein K63-linked ubiquitination]
GO:1902524 [positive regulation of protein K48-linked ubiquitination]
GO:1902527 [positive regulation of protein monoubiquitination]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
GO:2000116 [regulation of cysteine-type endopeptidase activity]
GO:2000377 [regulation of reactive oxygen species metabolic process]
Show all
 618 aa
69.9 kDa 		No 0
BIRC2-202
ENSP00000484838
ENST00000621637
A0A087X2B2 [Direct mapping]
Baculoviral IAP repeat-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0042981 [regulation of apoptotic process]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0060546 [negative regulation of necroptotic process]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 534 aa
60.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.