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The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Q13490 [Direct mapping] Baculoviral IAP repeat-containing protein 2
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Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000209 [protein polyubiquitination] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003713 [transcription coactivator activity] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0007166 [cell surface receptor signaling pathway] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0008270 [zinc ion binding] GO:0009898 [cytoplasmic side of plasma membrane] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0010939 [regulation of necrotic cell death] GO:0012501 [programmed cell death] GO:0016874 [ligase activity] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034121 [regulation of toll-like receptor signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035631 [CD40 receptor complex] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038061 [NIK/NF-kappaB signaling] GO:0039535 [regulation of RIG-I signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045087 [innate immune response] GO:0045088 [regulation of innate immune response] GO:0045595 [regulation of cell differentiation] GO:0047485 [protein N-terminus binding] GO:0050727 [regulation of inflammatory response] GO:0051726 [regulation of cell cycle] GO:0060544 [regulation of necroptotic process] GO:0060546 [negative regulation of necroptotic process] GO:0070266 [necroptotic process] GO:0070424 [regulation of nucleotide-binding oligomerization domain containing signaling pathway] GO:0097300 [programmed necrotic cell death] GO:1902523 [positive regulation of protein K63-linked ubiquitination] GO:1902524 [positive regulation of protein K48-linked ubiquitination] GO:1902527 [positive regulation of protein monoubiquitination] GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process] GO:2000116 [regulation of cysteine-type endopeptidase activity]