Cell atlas - UBE4A - The Human Protein Atlas

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UBE4A

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	UBE4A
Gene description	Ubiquitination factor E4A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (supported)
Mouse	Localized to the Nuclear speckles in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA055035 , HPA064010
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA055035	A-431	Nuclear speckles
HPA055035	CACO-2	Nuclear speckles
HPA055035	U-2 OS	Nuclear speckles
HPA064010	MCF7	Nucleoli fibrillar center
HPA064010	MCF7	Nuclear speckles
HPA064010	SiHa	Nuclear speckles
HPA064010	U-2 OS	Nuclear speckles

MOUSE CELLS

Main location

Nuclear speckles

Mouse gene

ENSMUSG00000059890 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA055035	NIH 3T3	Nuclear speckles

GENE INFORMATION
Gene name	UBE4A (HGNC Symbol)
Synonyms	E4, KIAA0126, UBOX2, UFD2
Description	Ubiquitination factor E4A (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	118359585 - 118399211
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110344 (version 83.38)
Entrez gene	9354
UniProt	Q14139 (UniProt - Evidence at protein level)
neXtProt	NX_Q14139
Antibodypedia	UBE4A antibodies

PROTEIN BROWSER

UBE4A-001	UBE4A-002	UBE4A-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UBE4A-001 ENSP00000252108 ENST00000252108	Q14139 [Direct mapping] Ubiquitin conjugation factor E4 A Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0034450 [ubiquitin-ubiquitin ligase activity] Show all	1066 aa 122.6 kDa	No	0
UBE4A-002 ENSP00000387362 ENST00000431736	Q14139 [Direct mapping] Ubiquitin conjugation factor E4 A Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0000209 [protein polyubiquitination] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0034450 [ubiquitin-ubiquitin ligase activity] GO:0061630 [ubiquitin protein ligase activity] Show all	1073 aa 123.5 kDa	No	0
UBE4A-003 ENSP00000438918 ENST00000545354	B7Z7P0 [Direct mapping] Ubiquitin conjugation factor E4 A; cDNA FLJ51394, highly similar to Ubiquitin conjugation factor E4 A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0004842 [ubiquitin-protein transferase activity] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0034450 [ubiquitin-ubiquitin ligase activity] Show all	538 aa 62 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.