Fields »
ABOUT
HELP
BLOG
UBE4A

GENERAL INFORMATION

Gene name

 UBE4A

Gene description

 Ubiquitination factor E4A

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA055035
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA055035

GENE INFORMATION

Gene name

 UBE4A (HGNC Symbol)

Synonyms

 E4, KIAA0126, UBOX2, UFD2

Description

 Ubiquitination factor E4A (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 118359585 - 118399211

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110344 (version 83.38)

Entrez gene

 9354

UniProt

 Q14139 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14139

Antibodypedia

 UBE4A antibodies

PROTEIN BROWSER
UBE4A-001
UBE4A-002
UBE4A-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBE4A-001
ENSP00000252108
ENST00000252108
Q14139 [Direct mapping]
Ubiquitin conjugation factor E4 A
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0034450 [ubiquitin-ubiquitin ligase activity]
Show all
 1066 aa
122.6 kDa 		No 0
UBE4A-002
ENSP00000387362
ENST00000431736
Q14139 [Direct mapping]
Ubiquitin conjugation factor E4 A
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0034450 [ubiquitin-ubiquitin ligase activity]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 1073 aa
123.5 kDa 		No 0
UBE4A-003
ENSP00000438918
ENST00000545354
B7Z7P0 [Direct mapping]
Ubiquitin conjugation factor E4 A; cDNA FLJ51394, highly similar to Ubiquitin conjugation factor E4 A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0034450 [ubiquitin-ubiquitin ligase activity]
Show all
 538 aa
62 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.