Expression of UPK2 in cancer - Summary - The Human Protein Atlas

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UPK2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	UPK2
Gene description	Uroplakin 2
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (urothelial cancer)
HPA (cell line):	Cell line enhanced (MCF7, RT4)
HPA (normal tissue):	Tissue enriched (urinary bladder)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in urinary bladder.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA043312 , HPA061106
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (urothelial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043312	HPA061106

GENE INFORMATION
Gene name	UPK2 (HGNC Symbol)
Synonyms	MGC138598, UP2, UPII
Description	Uroplakin 2 (HGNC Symbol)
Entrez gene summary	This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009]
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	118925164 - 118958559
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110375 (version 83.38)
Entrez gene	7379
UniProt	O00526 (UniProt - Evidence at protein level)
neXtProt	NX_O00526
Antibodypedia	UPK2 antibodies

PROTEIN BROWSER

UPK2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UPK2-001 ENSP00000264031 ENST00000264031	O00526 [Direct mapping] Uroplakin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007275 [multicellular organismal development] GO:0016324 [apical plasma membrane] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030855 [epithelial cell differentiation] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	184 aa 19.4 kDa	Yes	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.