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UPK2

GENERAL INFORMATION

Gene name

 UPK2

Gene description

 Uroplakin 2

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (urinary bladder)
GTEx:Tissue enriched (urinary bladder)
FANTOM5:Tissue enhanced (prostate, urinary bladder, vagina)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous expression in urinary bladder.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA043312 , HPA061106
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (urinary bladder)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (urinary bladder)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (prostate, urinary bladder, vagina)

GENE INFORMATION

Gene name

 UPK2 (HGNC Symbol)

Synonyms

 MGC138598, UP2, UPII

Description

 Uroplakin 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 118925164 - 118958559

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110375 (version 83.38)

Entrez gene

 7379

UniProt

 O00526 (UniProt - Evidence at protein level)

neXtProt

 NX_O00526

Antibodypedia

 UPK2 antibodies

PROTEIN BROWSER
UPK2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UPK2-001
ENSP00000264031
ENST00000264031
O00526 [Direct mapping]
Uroplakin-2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
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GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0007275 [multicellular organismal development]
GO:0016324 [apical plasma membrane]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030855 [epithelial cell differentiation]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
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 184 aa
19.4 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.