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SOX6

GENERAL INFORMATION

Gene name

 SOX6

Gene description

 SRY (sex determining region Y)-box 6

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (WM-115)
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in several tissues, including testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA001923 , HPA003908
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA001923
HPA003908

GENE INFORMATION

Gene name

 SOX6

Synonyms

Description

 SRY (sex determining region Y)-box 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Chromosome

 11

Cytoband

 p15.2

Chromosome location (bp)

 15966449 - 16739591

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110693 (version 83.38)

Entrez gene

 55553

UniProt

 P35712 (UniProt - Evidence at protein level)

neXtProt

 NX_P35712

Antibodypedia

 SOX6 antibodies

PROTEIN BROWSER
SOX6-001
SOX6-002
SOX6-003
SOX6-008
SOX6-009
SOX6-010
SOX6-012
SOX6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SOX6-001
ENSP00000324948
ENST00000316399
P35712 [Direct mapping]
Transcription factor SOX-6
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Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
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GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007517 [muscle organ development]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0061036 [positive regulation of cartilage development]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:2000741 [positive regulation of mesenchymal stem cell differentiation]
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 808 aa
89.7 kDa 		No 0
SOX6-002
ENSP00000432134
ENST00000528252
P35712 [Direct mapping]
Transcription factor SOX-6
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Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007517 [muscle organ development]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0061036 [positive regulation of cartilage development]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:2000741 [positive regulation of mesenchymal stem cell differentiation]
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 801 aa
89 kDa 		No 0
SOX6-003
ENSP00000434455
ENST00000527619
P35712 [Direct mapping]
Transcription factor SOX-6
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007517 [muscle organ development]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0061036 [positive regulation of cartilage development]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:2000741 [positive regulation of mesenchymal stem cell differentiation]
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 804 aa
89.3 kDa 		No 0
SOX6-008
ENSP00000432596
ENST00000529469
E9PQ67 [Direct mapping]
Transcription factor SOX-6
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Predicted intracellular proteins
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 79 aa
8.7 kDa 		No 0
SOX6-009
ENSP00000436170
ENST00000533411
E9PQL4 [Direct mapping]
Transcription factor SOX-6
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Predicted intracellular proteins
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GO:0003677 [DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
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 159 aa
17.8 kDa 		No 0
SOX6-010
ENSP00000434892
ENST00000526673
E9PN02 [Direct mapping]
Transcription factor SOX-6
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Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
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 139 aa
15.5 kDa 		No 0
SOX6-012
ENSP00000433233
ENST00000528429
P35712 [Direct mapping]
Transcription factor SOX-6
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007517 [muscle organ development]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0061036 [positive regulation of cartilage development]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:2000741 [positive regulation of mesenchymal stem cell differentiation]
Show all
 828 aa
91.9 kDa 		No 0
SOX6-201
ENSP00000379644
ENST00000396356
P35712 [Direct mapping]
Transcription factor SOX-6
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000902 [cell morphogenesis]
GO:0001701 [in utero embryonic development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007517 [muscle organ development]
GO:0009791 [post-embryonic development]
GO:0010468 [regulation of gene expression]
GO:0016458 [gene silencing]
GO:0021778 [oligodendrocyte cell fate specification]
GO:0030097 [hemopoiesis]
GO:0030218 [erythrocyte differentiation]
GO:0032332 [positive regulation of chondrocyte differentiation]
GO:0042692 [muscle cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045165 [cell fate commitment]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048708 [astrocyte differentiation]
GO:0048709 [oligodendrocyte differentiation]
GO:0048821 [erythrocyte development]
GO:0051216 [cartilage development]
GO:0055007 [cardiac muscle cell differentiation]
GO:0061036 [positive regulation of cartilage development]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:2000741 [positive regulation of mesenchymal stem cell differentiation]
Show all
 808 aa
89.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.