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Most cancer tissues showed weak to moderate cytoplasmic positivity. Few cases of melanomas, stomach and pancreatic cancers showed strong staining.
GENE INFORMATION
Gene name
AIP (HGNC Symbol)
Synonyms
ARA9, FKBP16, XAP2
Description
Aryl hydrocarbon receptor interacting protein (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]