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AIP

GENERAL INFORMATION

Gene name

 AIP

Gene description

 Aryl hydrocarbon receptor interacting protein

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
CAB033674 , CAB069477
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 AIP (HGNC Symbol)

Synonyms

 ARA9, FKBP16, XAP2

Description

 Aryl hydrocarbon receptor interacting protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Chromosome

 11

Cytoband

 q13.2

Chromosome location (bp)

 67483041 - 67491103

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110711 (version 83.38)

Entrez gene

 9049

UniProt

 O00170 (UniProt - Evidence at protein level)

neXtProt

 NX_O00170

Antibodypedia

 AIP antibodies

PROTEIN BROWSER
AIP-001
AIP-005
AIP-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AIP-001
ENSP00000279146
ENST00000279146
O00170 [Direct mapping]
AH receptor-interacting protein
G9I2H4 [Target identity:100%; Query identity:100%]
Aryl hydrocarbon receptor interacting protein
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003712 [transcription cofactor activity]
GO:0003713 [transcription coactivator activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006626 [protein targeting to mitochondrion]
GO:0006805 [xenobiotic metabolic process]
GO:0007165 [signal transduction]
GO:0008134 [transcription factor binding]
GO:0010738 [regulation of protein kinase A signaling]
GO:0016020 [membrane]
GO:0017162 [aryl hydrocarbon receptor binding]
GO:0022417 [protein maturation by protein folding]
GO:0034751 [aryl hydrocarbon receptor complex]
GO:0036004 [GAF domain binding]
GO:0051082 [unfolded protein binding]
GO:0051344 [negative regulation of cyclic-nucleotide phosphodiesterase activity]
GO:1903506 [regulation of nucleic acid-templated transcription]
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 330 aa
37.7 kDa 		No 0
AIP-005
ENSP00000476993
ENST00000525341
V9GYQ3 [Direct mapping]
AH receptor-interacting protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 188 aa
21.6 kDa 		No 0
AIP-006
ENSP00000434982
ENST00000528641
E9PMH2 [Direct mapping]
AH receptor-interacting protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006457 [protein folding]
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 232 aa
26.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.