Expression of P3H3 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

P3H3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	P3H3
Gene description	Prolyl 3-hydroxylase 3
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BJ)
HPA (normal tissue):	Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA043695
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043695

GENE INFORMATION
Gene name	P3H3 (HGNC Symbol)
Synonyms	GRCB, HSU47926, LEPREL2
Description	Prolyl 3-hydroxylase 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor. [provided by RefSeq, Aug 2013]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6828410 - 6839851
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110811 (version 83.38)
Entrez gene	10536
UniProt	Q8IVL6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IVL6
Antibodypedia	P3H3 antibodies

PROTEIN BROWSER

P3H3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
P3H3-002 ENSP00000478600 ENST00000290510	Q8IVL6 [Direct mapping] Prolyl 3-hydroxylase 3 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0005788 [endoplasmic reticulum lumen] GO:0008285 [negative regulation of cell proliferation] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0019511 [peptidyl-proline hydroxylation] GO:0019797 [procollagen-proline 3-dioxygenase activity] GO:0030198 [extracellular matrix organization] GO:0031418 [L-ascorbic acid binding] GO:0055114 [oxidation-reduction process] Show all	736 aa 81.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.