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P3H3

GENERAL INFORMATION

Gene name

 P3H3

Gene description

 Prolyl 3-hydroxylase 3

Protein class

 Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (parathyroid gland)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA043695
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 P3H3 (HGNC Symbol)

Synonyms

 GRCB, HSU47926, LEPREL2

Description

 Prolyl 3-hydroxylase 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the leprecan family of proteoglycans, which function as collagen prolyl hydroxylases that are required for proper collagen biosynthesis, folding and assembly. This protein, like other family members, is thought to reside in the endoplasmic reticulum. Epigenetic inactivation of this gene is associated with breast and other cancers, suggesting that it may function as a tumor suppressor. [provided by RefSeq, Aug 2013]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 6828410 - 6839851

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110811 (version 83.38)

Entrez gene

 10536

UniProt

 Q8IVL6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IVL6

Antibodypedia

 P3H3 antibodies

PROTEIN BROWSER
P3H3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
P3H3-002
ENSP00000478600
ENST00000290510
Q8IVL6 [Direct mapping]
Prolyl 3-hydroxylase 3
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005506 [iron ion binding]
GO:0005788 [endoplasmic reticulum lumen]
GO:0008285 [negative regulation of cell proliferation]
GO:0016491 [oxidoreductase activity]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0019511 [peptidyl-proline hydroxylation]
GO:0019797 [procollagen-proline 3-dioxygenase activity]
GO:0030198 [extracellular matrix organization]
GO:0031418 [L-ascorbic acid binding]
GO:0055114 [oxidation-reduction process]
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 736 aa
81.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.