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DAO

GENERAL INFORMATION

Gene name

 DAO

Gene description

 D-amino-acid oxidase

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Not detected
HPA (normal tissue):Group enriched (kidney, liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in hepatocytes and renal tubules.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA038653 , HPA038654
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038653
HPA038654

GENE INFORMATION

Gene name

 DAO (HGNC Symbol)

Synonyms

 DAMOX

Description

 D-amino-acid oxidase (HGNC Symbol)

Entrez gene summary

 This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q24.11

Chromosome location (bp)

 108858932 - 108901043

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110887 (version 83.38)

Entrez gene

 1610

UniProt

 P14920 (UniProt - Evidence at protein level)

neXtProt

 NX_P14920

Antibodypedia

 DAO antibodies

PROTEIN BROWSER
DAO-001
DAO-006
DAO-008
DAO-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DAO-001
ENSP00000228476
ENST00000228476
P14920 [Direct mapping]
D-amino-acid oxidase
A0A024RBI1 [Target identity:100%; Query identity:100%]
D-amino-acid oxidase, isoform CRA_c
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0003884 [D-amino-acid oxidase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005741 [mitochondrial outer membrane]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0005782 [peroxisomal matrix]
GO:0005829 [cytosol]
GO:0006562 [proline catabolic process]
GO:0016491 [oxidoreductase activity]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0036088 [D-serine catabolic process]
GO:0042416 [dopamine biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0046416 [D-amino acid metabolic process]
GO:0046487 [glyoxylate metabolic process]
GO:0046983 [protein dimerization activity]
GO:0048037 [cofactor binding]
GO:0055114 [oxidation-reduction process]
GO:0055130 [D-alanine catabolic process]
GO:0070178 [D-serine metabolic process]
GO:0071949 [FAD binding]
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 347 aa
39.5 kDa 		No 0
DAO-006
ENSP00000446853
ENST00000551281
A0A0B4J250 [Direct mapping]
D-amino-acid oxidase
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0003884 [D-amino-acid oxidase activity]
GO:0016491 [oxidoreductase activity]
GO:0046416 [D-amino acid metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0071949 [FAD binding]
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 281 aa
31.5 kDa 		Yes 0
DAO-008
ENSP00000449967
ENST00000547768
F8VV35 [Direct mapping]
D-amino-acid oxidase
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Predicted intracellular proteins
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GO:0003884 [D-amino-acid oxidase activity]
GO:0016491 [oxidoreductase activity]
GO:0046416 [D-amino acid metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0071949 [FAD binding]
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 167 aa
19.3 kDa 		No 0
DAO-009
ENSP00000447104
ENST00000547166
F8W152 [Direct mapping]
D-amino-acid oxidase
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   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0003884 [D-amino-acid oxidase activity]
GO:0016491 [oxidoreductase activity]
GO:0046416 [D-amino acid metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0071949 [FAD binding]
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 197 aa
22.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.