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ATP5B

GENERAL INFORMATION

Gene name

 ATP5B

Gene description

 ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous granular cytoplasmic expressed.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA001520 , HPA001528 , CAB017527
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and breast cancer (unfavourable).
Renal cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA001520
HPA001528
CAB017527

GENE INFORMATION

Gene name

 ATP5B (HGNC Symbol)

Synonyms

 ATPSB

Description

 ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 56638175 - 56646068

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110955 (version 83.38)

Entrez gene

 506

UniProt

 P06576 (UniProt - Evidence at protein level)

neXtProt

 NX_P06576

Antibodypedia

 ATP5B antibodies

PROTEIN BROWSER
ATP5B-003
ATP5B-004
ATP5B-009
ATP5B-010
ATP5B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP5B-003
ENSP00000446677
ENST00000551020
F8W079 [Direct mapping]
ATP synthase subunit beta, mitochondrial
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances]
GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain]
GO:0046034 [ATP metabolic process]
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 284 aa
30.2 kDa 		No 0
ATP5B-004
ENSP00000446489
ENST00000552959
H0YH81 [Direct mapping]
ATP synthase subunit beta
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015992 [proton transport]
GO:0045261 [proton-transporting ATP synthase complex, catalytic core F(1)]
GO:0046034 [ATP metabolic process]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
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 362 aa
38.1 kDa 		No 0
ATP5B-009
ENSP00000447571
ENST00000553007
F8W0P7 [Direct mapping]
ATP synthase subunit beta, mitochondrial
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0015992 [proton transport]
GO:0046034 [ATP metabolic process]
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 270 aa
28.4 kDa 		No 0
ATP5B-010
ENSP00000448428
ENST00000551570
H0YI37 [Direct mapping]
ATP synthase subunit beta, mitochondrial
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
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GO:0005524 [ATP binding]
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 133 aa
13.9 kDa 		No 0
ATP5B-201
ENSP00000262030
ENST00000262030
P06576 [Direct mapping]
ATP synthase subunit beta, mitochondrial
V9HW31 [Target identity:100%; Query identity:100%]
ATP synthase subunit beta
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001649 [osteoblast differentiation]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0005754 [mitochondrial proton-transporting ATP synthase, catalytic core]
GO:0005759 [mitochondrial matrix]
GO:0005886 [plasma membrane]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006629 [lipid metabolic process]
GO:0006754 [ATP biosynthetic process]
GO:0006933 [negative regulation of cell adhesion involved in substrate-bound cell migration]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0009986 [cell surface]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016020 [membrane]
GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances]
GO:0016887 [ATPase activity]
GO:0022857 [transmembrane transporter activity]
GO:0022904 [respiratory electron transport chain]
GO:0031966 [mitochondrial membrane]
GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain]
GO:0042288 [MHC class I protein binding]
GO:0042645 [mitochondrial nucleoid]
GO:0042776 [mitochondrial ATP synthesis coupled proton transport]
GO:0043209 [myelin sheath]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046034 [ATP metabolic process]
GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0051453 [regulation of intracellular pH]
GO:0070062 [extracellular exosome]
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 529 aa
56.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.