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KRT18

GENERAL INFORMATION

Gene name

 KRT18

Gene description

 Keratin 18, type I

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (A549, CACO-2, CAPAN-2, MCF7)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression mainly in glandular epithelium.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA001605 , CAB000008 , CAB000030
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and lung cancer (unfavourable).
Pancreatic cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001605
CAB000008
CAB000030

GENE INFORMATION

Gene name

 KRT18

Synonyms

Description

 Keratin 18, type I (HGNC Symbol)

Entrez gene summary

 KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 52948871 - 52952901

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111057 (version 83.38)

Entrez gene

 3875

UniProt

 P05783 (UniProt - Evidence at protein level)

neXtProt

 NX_P05783

Antibodypedia

 KRT18 antibodies

PROTEIN BROWSER
KRT18-001
KRT18-002
KRT18-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT18-001
ENSP00000447278
ENST00000550600
F8VZY9 [Direct mapping]
Keratin, type I cytoskeletal 18
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005737 [cytoplasm]
GO:0005882 [intermediate filament]
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 391 aa
43.8 kDa 		No 0
KRT18-002
ENSP00000373487
ENST00000388835
P05783 [Direct mapping]
Keratin, type I cytoskeletal 18
A0A024RAY2 [Target identity:100%; Query identity:100%]
Keratin 18, isoform CRA_a
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005882 [intermediate filament]
GO:0007049 [cell cycle]
GO:0009653 [anatomical structure morphogenesis]
GO:0016032 [viral process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034451 [centriolar satellite]
GO:0043000 [Golgi to plasma membrane CFTR protein transport]
GO:0043066 [negative regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0045095 [keratin filament]
GO:0045104 [intermediate filament cytoskeleton organization]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0097110 [scaffold protein binding]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097284 [hepatocyte apoptotic process]
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 430 aa
48.1 kDa 		No 0
KRT18-201
ENSP00000373489
ENST00000388837
P05783 [Direct mapping]
Keratin, type I cytoskeletal 18
A0A024RAY2 [Target identity:100%; Query identity:100%]
Keratin 18, isoform CRA_a
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005882 [intermediate filament]
GO:0007049 [cell cycle]
GO:0009653 [anatomical structure morphogenesis]
GO:0016032 [viral process]
GO:0034451 [centriolar satellite]
GO:0043000 [Golgi to plasma membrane CFTR protein transport]
GO:0043066 [negative regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0045095 [keratin filament]
GO:0045104 [intermediate filament cytoskeleton organization]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0097110 [scaffold protein binding]
Show all
 430 aa
48.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.