Expression of ACSS3 in cancer - Summary - The Human Protein Atlas

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ACSS3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACSS3
Gene description	Acyl-CoA synthetase short-chain family member 3
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (Hep G2, RH-30, SK-BR-3)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA039353 , HPA047956
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039353	HPA047956

GENE INFORMATION
Gene name	ACSS3 (HGNC Symbol)
Synonyms	FLJ21963
Description	Acyl-CoA synthetase short-chain family member 3 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q21.31
Chromosome location (bp)	80936414 - 81261205
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111058 (version 83.38)
Entrez gene	79611
UniProt	Q9H6R3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H6R3
Antibodypedia	ACSS3 antibodies

PROTEIN BROWSER

ACSS3-001	ACSS3-002	ACSS3-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACSS3-001 ENSP00000449535 ENST00000548058	Q9H6R3 [Direct mapping] Acyl-CoA synthetase short-chain family member 3, mitochondrial Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003987 [acetate-CoA ligase activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0008152 [metabolic process] Show all	686 aa 74.8 kDa	No	1
ACSS3-002 ENSP00000261206 ENST00000261206	A0A0B4J1R2 [Direct mapping] Acyl-CoA synthetase short-chain family member 3, mitochondrial; FLJ21963 protein, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	685 aa 74.6 kDa	No	1
ACSS3-007 ENSP00000447748 ENST00000549175	F8VZB4 [Direct mapping] Acyl-CoA synthetase short-chain family member 3, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	93 aa 10.2 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.