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ENDOU

GENERAL INFORMATION

Gene name

 ENDOU

Gene description

 Endonuclease, polyU-specific

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (head and neck cancer)
HPA (cell line):Cell line enhanced (Daudi, SK-BR-3)
HPA (normal tissue):Group enriched (esophagus, skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in placenta and squamous epithelia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA012388 , HPA067448
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA012388
HPA067448

GENE INFORMATION

Gene name

 ENDOU (HGNC Symbol)

Synonyms

 P11, PP11, PRSS26

Description

 Endonuclease, polyU-specific (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein with protease activity and is expressed in the placenta. The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants have been found for this protein. [provided by RefSeq, Feb 2010]

Chromosome

 12

Cytoband

 q13.11

Chromosome location (bp)

 47709734 - 47725567

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111405 (version 83.38)

Entrez gene

 8909

UniProt

 P21128 (UniProt - Evidence at protein level)

neXtProt

 NX_P21128

Antibodypedia

 ENDOU antibodies

PROTEIN BROWSER
ENDOU-001
ENDOU-002
ENDOU-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ENDOU-001
ENSP00000229003
ENST00000229003
P21128 [Direct mapping]
Poly(U)-specific endoribonuclease
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0004521 [endoribonuclease activity]
GO:0005044 [scavenger receptor activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006898 [receptor-mediated endocytosis]
GO:0006955 [immune response]
GO:0007565 [female pregnancy]
GO:0008083 [growth factor activity]
GO:0008236 [serine-type peptidase activity]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0030145 [manganese ion binding]
GO:0030247 [polysaccharide binding]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
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 369 aa
42.1 kDa 		Yes 0
ENDOU-002
ENSP00000397679
ENST00000422538
P21128 [Direct mapping]
Poly(U)-specific endoribonuclease
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0004521 [endoribonuclease activity]
GO:0005044 [scavenger receptor activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006898 [receptor-mediated endocytosis]
GO:0006955 [immune response]
GO:0007565 [female pregnancy]
GO:0008083 [growth factor activity]
GO:0008236 [serine-type peptidase activity]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0030145 [manganese ion binding]
GO:0030247 [polysaccharide binding]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 410 aa
46.9 kDa 		Yes 0
ENDOU-003
ENSP00000445004
ENST00000545824
P21128 [Direct mapping]
Poly(U)-specific endoribonuclease
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0004521 [endoribonuclease activity]
GO:0005044 [scavenger receptor activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006898 [receptor-mediated endocytosis]
GO:0006955 [immune response]
GO:0007565 [female pregnancy]
GO:0008083 [growth factor activity]
GO:0008236 [serine-type peptidase activity]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0030145 [manganese ion binding]
GO:0030247 [polysaccharide binding]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 347 aa
39.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.