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Tissue enhanced (appendix, bone marrow, lymph node)
Protein evidence
Evidence at protein level
Protein expression normal tissue
Distinct plasma staining.
ANTIBODY IHC RELIABILITY
Data reliability description
Secreted protein, tissue location of RNA and protein might differ and correlation is complex. External characterization data supports antibody staining.
Most malignancies showed weak cytoplasmic positivity in a few cases while the remaining cells were negative.
GENE INFORMATION
Gene name
IFNG
Synonyms
Description
Interferon, gamma (HGNC Symbol)
Entrez gene summary
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of the both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial inflections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Sep 2015]