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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

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Score

Score

Score

Antibodies

Column

 
 
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IFNG
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

IFNG

Gene description

Interferon, gamma

Protein class

Cancer-related genes
Disease related genes
FDA approved drug targets
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (appendix, bone marrow, lymph node)
GTEx:Tissue enhanced (lung)
FANTOM5:Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein expression

Distinct plasma staining.

DATA RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. External characterization data supports antibody staining.

Reliability score

Approved based on 1 antibody.
CAB010344
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, bone marrow, lymph node)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung)

GENE INFORMATION

Gene name

IFNG

Synonyms

Description

Interferon, gamma (HGNC Symbol)

Entrez gene summary

This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of the both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial inflections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Sep 2015]

Chromosome

12

Cytoband

q15

Chromosome location (bp)

68154768 - 68159747

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000111537 (version 83.38)

Entrez gene

3458

UniProt

P01579 (UniProt - Evidence at protein level)

neXtProt

NX_P01579

Antibodypedia

IFNG antibodies

PROTEIN BROWSER

IFNG-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IFNG-001
ENSP00000229135
ENST00000229135
P01579 [Direct mapping]
Interferon gamma
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001781 [neutrophil apoptotic process]
GO:0002026 [regulation of the force of heart contraction]
GO:0002250 [adaptive immune response]
GO:0002302 [CD8-positive, alpha-beta T cell differentiation involved in immune response]
GO:0005125 [cytokine activity]
GO:0005133 [interferon-gamma receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006925 [inflammatory cell apoptotic process]
GO:0006928 [movement of cell or subcellular component]
GO:0006955 [immune response]
GO:0006959 [humoral immune response]
GO:0007050 [cell cycle arrest]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0009615 [response to virus]
GO:0009897 [external side of plasma membrane]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019882 [antigen processing and presentation]
GO:0030593 [neutrophil chemotaxis]
GO:0030857 [negative regulation of epithelial cell differentiation]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031642 [negative regulation of myelination]
GO:0032224 [positive regulation of synaptic transmission, cholinergic]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032747 [positive regulation of interleukin-23 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032834 [positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response]
GO:0033141 [positive regulation of peptidyl-serine phosphorylation of STAT protein]
GO:0034393 [positive regulation of smooth muscle cell apoptotic process]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042493 [response to drug]
GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042742 [defense response to bacterium]
GO:0042832 [defense response to protozoan]
GO:0044130 [negative regulation of growth of symbiont in host]
GO:0044146 [negative regulation of growth of symbiont involved in interaction with host]
GO:0045080 [positive regulation of chemokine biosynthetic process]
GO:0045084 [positive regulation of interleukin-12 biosynthetic process]
GO:0045348 [positive regulation of MHC class II biosynthetic process]
GO:0045410 [positive regulation of interleukin-6 biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0045785 [positive regulation of cell adhesion]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048304 [positive regulation of isotype switching to IgG isotypes]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050776 [regulation of immune response]
GO:0050796 [regulation of insulin secretion]
GO:0050954 [sensory perception of mechanical stimulus]
GO:0051044 [positive regulation of membrane protein ectodomain proteolysis]
GO:0051607 [defense response to virus]
GO:0051712 [positive regulation of killing of cells of other organism]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060550 [positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity]
GO:0060552 [positive regulation of fructose 1,6-bisphosphate metabolic process]
GO:0060557 [positive regulation of vitamin D biosynthetic process]
GO:0060559 [positive regulation of calcidiol 1-monooxygenase activity]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071351 [cellular response to interleukin-18]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0098908 [regulation of neuronal action potential]
GO:2000309 [positive regulation of tumor necrosis factor (ligand) superfamily member 11 production]
GO:2000345 [regulation of hepatocyte proliferation]
Show all
166 aa
19.3 kDa
Yes 0

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