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CHD4

GENERAL INFORMATION

Gene name

 CHD4

Gene description

 Chromodomain helicase DNA binding protein 4

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA012008
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA012008

GENE INFORMATION

Gene name

 CHD4 (HGNC Symbol)

Synonyms

 Mi-2b, Mi2-BETA

Description

 Chromodomain helicase DNA binding protein 4 (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 6570083 - 6607476

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111642 (version 83.38)

Entrez gene

 1108

UniProt

 Q14839 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14839

Antibodypedia

 CHD4 antibodies

PROTEIN BROWSER
CHD4-002
CHD4-003
CHD4-004
CHD4-013
CHD4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHD4-002
ENSP00000440542
ENST00000544040
F5GWX5 [Direct mapping]
Chromodomain-helicase-DNA-binding protein 4
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   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008017 [microtubule binding]
GO:0008026 [ATP-dependent helicase activity]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016581 [NuRD complex]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0051225 [spindle assembly]
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 1905 aa
217.1 kDa 		No 0
CHD4-003
ENSP00000437506
ENST00000545942
F5H6N4 [Direct mapping]
Chromodomain-helicase-DNA-binding protein 4
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016581 [NuRD complex]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0051225 [spindle assembly]
Show all
 354 aa
39.1 kDa 		No 0
CHD4-004
ENSP00000444614
ENST00000545584
F5H596 [Direct mapping]
Chromodomain-helicase-DNA-binding protein 4
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
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 125 aa
13.8 kDa 		No 0
CHD4-013
ENSP00000440392
ENST00000544484
A0A0C4DGG9 [Direct mapping]
Chromodomain-helicase-DNA-binding protein 4
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008017 [microtubule binding]
GO:0008026 [ATP-dependent helicase activity]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016581 [NuRD complex]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0051225 [spindle assembly]
Show all
 1937 aa
220.5 kDa 		No 0
CHD4-201
ENSP00000349508
ENST00000357008
Q14839 [Direct mapping]
Chromodomain-helicase-DNA-binding protein 4
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008017 [microtubule binding]
GO:0008026 [ATP-dependent helicase activity]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016581 [NuRD complex]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0031492 [nucleosomal DNA binding]
GO:0032508 [DNA duplex unwinding]
GO:0032993 [protein-DNA complex]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0051225 [spindle assembly]
GO:0072553 [terminal button organization]
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 1912 aa
218 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.